Possible interventions to modify aging

Giacinto Libertini, Nicola Ferrara

Research output: Contribution to journalArticlepeer-review


The programmed aging paradigm interprets aging as a function favored by natural selection at a supra-individual level. This function is implemented, according to the telomere theory, through mechanisms that operate through the subtelomere–telomere–telomerase system. After reviewing some necessary technical and ethical reservations and providing a concise description of aging mechanisms, this work considers interventions that could lead to the control of some highly disabling characteristics of aging, such as Alzheimer’s and Parkinson’s syndromes and age-related macular degeneration, and afterwards to a full control of aging up to a condition equivalent to that of the species defined as “with negligible senescence”. The various steps needed for the development of such interventions are described along general lines.

Original languageEnglish
Pages (from-to)1413-1428
Number of pages16
JournalBiochemistry (Moscow)
Issue number12
Publication statusPublished - Dec 1 2016


  • aging
  • Alzheimer
  • Parkinson
  • programmed aging paradigm
  • subtelomere
  • telomere

ASJC Scopus subject areas

  • Biochemistry


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