Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Q. Wang; M. E. Curran; I. Splawski; T. C. Burn; J. M. Millholland; T. J. VanRaay; J. Shen; K. W. Timothy; G. M. Vincent; T. De Jager; P. J. Schwartz; J. A. Towbin; A. J. Moss; D. L. Atkinson; G. M. Landes; T. D. Connors; M. T. Keating

doi:10.1038/ng0196-17

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Q. Wang, M. E. Curran, I. Splawski, T. C. Burn, J. M. Millholland, T. J. VanRaay, J. Shen, K. W. Timothy, G. M. Vincent, T. De Jager, P. J. Schwartz, J. A. Towbin, A. J. Moss, D. L. Atkinson, G. M. Landes, T. D. Connors, M. T. Keating

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic factors contribute to the risk of sudden death from cardiac arrhythmias. Here, positional cloning methods establish KVLQT1 as the chromosome 11-linked LQT1 gene responsible for the most common inherited cardiac arrhythmia. KVLQT1 is strongly expressed in the heart and encodes a protein with structural features of a voltage-gated potassium channel. KVLQT1 mutations are present in affected members of 16 arrhythmia families, including one intragenic deletion and ten different missense mutations. These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricular tachyarrhythmias and sudden death.

Original language	English
Pages (from-to)	17-23
Number of pages	7
Journal	Nature Genetics
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/ng0196-17
Publication status	Published - Jan 1996

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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Wang, Q., Curran, M. E., Splawski, I., Burn, T. C., Millholland, J. M., VanRaay, T. J., Shen, J., Timothy, K. W., Vincent, G. M., De Jager, T., Schwartz, P. J., Towbin, J. A., Moss, A. J., Atkinson, D. L., Landes, G. M., Connors, T. D., & Keating, M. T. (1996). Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nature Genetics, 12(1), 17-23. https://doi.org/10.1038/ng0196-17

Wang, Q, Curran, ME, Splawski, I, Burn, TC, Millholland, JM, VanRaay, TJ, Shen, J, Timothy, KW, Vincent, GM, De Jager, T, Schwartz, PJ, Towbin, JA, Moss, AJ, Atkinson, DL, Landes, GM, Connors, TD & Keating, MT 1996, 'Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias', Nature Genetics, vol. 12, no. 1, pp. 17-23. https://doi.org/10.1038/ng0196-17

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title = "Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias",

abstract = "Genetic factors contribute to the risk of sudden death from cardiac arrhythmias. Here, positional cloning methods establish KVLQT1 as the chromosome 11-linked LQT1 gene responsible for the most common inherited cardiac arrhythmia. KVLQT1 is strongly expressed in the heart and encodes a protein with structural features of a voltage-gated potassium channel. KVLQT1 mutations are present in affected members of 16 arrhythmia families, including one intragenic deletion and ten different missense mutations. These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricular tachyarrhythmias and sudden death.",

author = "Q. Wang and Curran, {M. E.} and I. Splawski and Burn, {T. C.} and Millholland, {J. M.} and VanRaay, {T. J.} and J. Shen and Timothy, {K. W.} and Vincent, {G. M.} and {De Jager}, T. and Schwartz, {P. J.} and Towbin, {J. A.} and Moss, {A. J.} and Atkinson, {D. L.} and Landes, {G. M.} and Connors, {T. D.} and Keating, {M. T.}",

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AU - Splawski, I.

AU - Burn, T. C.

AU - Millholland, J. M.

AU - VanRaay, T. J.

AU - Shen, J.

AU - Timothy, K. W.

AU - Vincent, G. M.

AU - De Jager, T.

AU - Schwartz, P. J.

AU - Towbin, J. A.

AU - Moss, A. J.

AU - Atkinson, D. L.

AU - Landes, G. M.

AU - Connors, T. D.

AU - Keating, M. T.

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N2 - Genetic factors contribute to the risk of sudden death from cardiac arrhythmias. Here, positional cloning methods establish KVLQT1 as the chromosome 11-linked LQT1 gene responsible for the most common inherited cardiac arrhythmia. KVLQT1 is strongly expressed in the heart and encodes a protein with structural features of a voltage-gated potassium channel. KVLQT1 mutations are present in affected members of 16 arrhythmia families, including one intragenic deletion and ten different missense mutations. These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricular tachyarrhythmias and sudden death.

AB - Genetic factors contribute to the risk of sudden death from cardiac arrhythmias. Here, positional cloning methods establish KVLQT1 as the chromosome 11-linked LQT1 gene responsible for the most common inherited cardiac arrhythmia. KVLQT1 is strongly expressed in the heart and encodes a protein with structural features of a voltage-gated potassium channel. KVLQT1 mutations are present in affected members of 16 arrhythmia families, including one intragenic deletion and ten different missense mutations. These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricular tachyarrhythmias and sudden death.

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Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

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