TY - JOUR
T1 - Portraying infective endocarditis
T2 - results of multinational ID-IRI study
AU - Erdem, Hakan
AU - Puca, Edmond
AU - Ruch, Yvon
AU - Santos, Lurdes
AU - Ghanem-Zoubi, Nesrin
AU - Argemi, Xavier
AU - Hansmann, Yves
AU - Guner, Rahmet
AU - Tonziello, Gilda
AU - Mazzucotelli, Jean Philippe
AU - Como, Najada
AU - Kose, Sukran
AU - Batirel, Ayse
AU - Inan, Asuman
AU - Tulek, Necla
AU - Pekok, Abdullah Umut
AU - Khan, Ejaz Ahmed
AU - Iyisoy, Atilla
AU - Meric-Koc, Meliha
AU - Kaya-Kalem, Ayse
AU - Martins, Pedro Palma
AU - Hasanoglu, Imran
AU - Silva-Pinto, André
AU - Oztoprak, Nefise
AU - Duro, Raquel
AU - Almajid, Fahad
AU - Dogan, Mustafa
AU - Dauby, Nicolas
AU - Gunst, Jesper Damsgaard
AU - Tekin, Recep
AU - Konopnicki, Deborah
AU - Petrosillo, Nicola
AU - Bozkurt, Ilkay
AU - Wadi, Jamal
AU - Popescu, Corneliu
AU - Balkan, Ilker Inanc
AU - Ozer-Balin, Safak
AU - Zupanc, Tatjana Lejko
AU - Cascio, Antonio
AU - Dumitru, Irina Magdalena
AU - Erdem, Aysegul
AU - Ersoz, Gulden
AU - Tasbakan, Meltem
AU - Ajamieh, Oday Abu
AU - Sirmatel, Fatma
AU - Florescu, Simin
AU - Gulsun, Serda
AU - Ozkaya, Hacer Deniz
AU - Sari, Sema
AU - Tosun, Selma
AU - Avci, Meltem
AU - Cag, Yasemin
AU - Celebi, Guven
AU - Sagmak-Tartar, Ayse
AU - Karakus, Sumeyra
AU - Sener, Alper
AU - Dedej, Arjeta
AU - Oncu, Serkan
AU - Del Vecchio, Rosa Fontana
AU - Ozturk-Engin, Derya
AU - Agalar, Canan
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).
AB - Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).
KW - Blood culture
KW - Infective endocarditis
KW - Native
KW - Prosthetic
KW - S. aureus
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U2 - 10.1007/s10096-019-03607-x
DO - 10.1007/s10096-019-03607-x
M3 - Article
AN - SCOPUS:85067399544
SN - 0934-9723
SP - 1753
EP - 1763
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
ER -