Polyphenols, Nerve Growth Factor, Brain-Derived Neurotrophic Factor, and the Brain

Valentina Carito, Mauro Ceccanti, George Chaldakov, Luigi Tarani, Sara De Nicolò, Stefania Ciafrè, Paola Tirassa, Marco Fiore

Research output: Chapter in Book/Report/Conference proceedingChapter


The central nervous system (CNS) has a limited capacity to spontaneously regenerate following traumatic injury or disease; therefore, the availability of new, innovative strategies to recover from the alteration in brain structure and function to promote tissue and functional repair would be of great importance. At the present time, many efforts have been carried out to identify strategies or drugs able to prevent or at least attenuate brain damage. This review summarizes the current knowledge of the major bioactivities and the efficacy on the brain of polyphenols and CNS active herbal remedies in order to stimulate interest in evaluating these compounds as potential sources for structurally and functionally novel CNS active drugs. We discuss the role of polyphenols in the brain and their functional implications for the healthy and diseased brain, especially with regard to their ability to modulate neurotrophin functions.

Original languageEnglish
Title of host publicationBioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy
PublisherElsevier Inc.
Number of pages7
ISBN (Print)9780124115293, 9780124114623
Publication statusPublished - Sept 11 2014


  • BDNF
  • Brain
  • Neurotrophins
  • NGF
  • Polyphenols

ASJC Scopus subject areas

  • Medicine(all)


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