Polyamines and estrogen-receptor concentrations in human colorectal carcinomas

F. Russo, M. Linsalata, C. Messa, A. Cavallini, M. Notarnicola, V. Guerra, G. Lantone, M. Lacatena, A. Di Leo

Research output: Contribution to journalArticlepeer-review


We assayed the estrogen receptors and polyamine levels (putrescine, spermidine and spermine) in the neoplastic and 'normal' surrounding tissue of patients with colorectal cancer. Polyamine levels and the spermidine/spermine ratio were significantly higher in the neoplastic tissue than in the 'normal' surrounding colonic mucosa of the same patients. Estrogen receptors were fewer in neoplastic mucosa than in the surrounding tissue, and polyamine levels were higher in estrogen-receptor negative tumours than in estrogen-receptor positive ones, although this was statistically significant only in the case of spermidine. Polyamine levels and estrogen receptor concentrations did not correlate with the tumour site, histological differentiation, or the age and sex of patients.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalItalian Journal of Gastroenterology
Issue number1
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Gastroenterology


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