Platelet Concentrates in Musculoskeletal Medicine

Research output: Contribution to journalReview articlepeer-review


Platelet concentrates (PCs), mostly represented by platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biological blood-derived products that may combine plasma/platelet-derived bioactive components, together with fibrin-forming protein able to create a natural three-dimensional scaffold. These types of products are safely used in clinical applications due to the autologous-derived source and the minimally invasive application procedure. In this narrative review, we focus on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculoskeletal medicine, efficacy and main limits of the different studies.

Original languageEnglish
Pages (from-to)1-24
Number of pages24
JournalInternational Journal of Molecular Sciences
Issue number4
Publication statusPublished - Feb 16 2020


  • composition
  • musculoskeletal diseases
  • platelet-rich fibrin
  • platelet-rich plasma
  • preparation


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