Abstract
The effects of two different calcium-channel blocking agents on platelet alpha-2 adrenoceptors were studied in 18 mild to moderate hypertensive patients. The subjects were randomly assigned in a double blind fashion to treatment with either nifedipine 10 mg t.i.d. or tiapamil 300 b.i.d. for six weeks. Platelet alpha-2 receptors were studied before and following 6 weeks of treatment using radioligand binding assay (3H Rauwolscine). Both agents induced a reduction in alpha-2 receptors, which reached statistical significance only for nifedipine. Such a reduction may contribute to the antihypertensive effect of calcium-channel blocking drugs.
| Translated title of the contribution | Platelet adrenergic alpha receptors in hypertensive subjects undergoing treatment with calcium antagonists |
|---|---|
| Original language | Italian |
| Pages (from-to) | 9-13 |
| Number of pages | 5 |
| Journal | Bollettino della Societa Italiana di Biologia Sperimentale |
| Volume | 66 |
| Issue number | 1 |
| Publication status | Published - Jan 1990 |
ASJC Scopus subject areas
- Medicine(all)