Phospholipase A2 (PLA2) and phenothiazines: Evidence for a correlation in blocking phagocyte function

A. Mazzone; S. Sacchi; R. Degiulio; P. Sacchi; G. Ricevuti

Phospholipase A₂ (PLA₂) and phenothiazines: Evidence for a correlation in blocking phagocyte function

A. Mazzone, S. Sacchi, R. Degiulio, P. Sacchi, G. Ricevuti

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

We studied some neutrophil functions i.e. chemotaxis, superoxide production and aggregation in 10 normal controls under resting conditions and after incubation with promazine (50-250 μg/ml). We measured concentrations of 6-Keto-Prostaglandin 1α(6KPGF 1α) and Leukotriene C₄(LTC₄) in the supernatants of neutrophil suspensions after phytohemagglutinin (PHA) induced aggregation. Promazine at all concentrations decreased neutrophil function and LTC₄ release.

Original language	English
Pages (from-to)	163-169
Number of pages	7
Journal	Hematology Reviews and Communications
Volume	2
Issue number	2
Publication status	Published - 1988

ASJC Scopus subject areas

Hematology

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title = "Phospholipase A2 (PLA2) and phenothiazines: Evidence for a correlation in blocking phagocyte function",

abstract = "We studied some neutrophil functions i.e. chemotaxis, superoxide production and aggregation in 10 normal controls under resting conditions and after incubation with promazine (50-250 μg/ml). We measured concentrations of 6-Keto-Prostaglandin 1α(6KPGF 1α) and Leukotriene C4(LTC4) in the supernatants of neutrophil suspensions after phytohemagglutinin (PHA) induced aggregation. Promazine at all concentrations decreased neutrophil function and LTC4 release.",

author = "A. Mazzone and S. Sacchi and R. Degiulio and P. Sacchi and G. Ricevuti",

year = "1988",

language = "English",

volume = "2",

pages = "163--169",

journal = "Hematology Reviews and Communications",

issn = "0882-8083",

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T1 - Phospholipase A2 (PLA2) and phenothiazines

T2 - Evidence for a correlation in blocking phagocyte function

AU - Mazzone, A.

AU - Sacchi, S.

AU - Degiulio, R.

AU - Sacchi, P.

AU - Ricevuti, G.

PY - 1988

Y1 - 1988

N2 - We studied some neutrophil functions i.e. chemotaxis, superoxide production and aggregation in 10 normal controls under resting conditions and after incubation with promazine (50-250 μg/ml). We measured concentrations of 6-Keto-Prostaglandin 1α(6KPGF 1α) and Leukotriene C4(LTC4) in the supernatants of neutrophil suspensions after phytohemagglutinin (PHA) induced aggregation. Promazine at all concentrations decreased neutrophil function and LTC4 release.

AB - We studied some neutrophil functions i.e. chemotaxis, superoxide production and aggregation in 10 normal controls under resting conditions and after incubation with promazine (50-250 μg/ml). We measured concentrations of 6-Keto-Prostaglandin 1α(6KPGF 1α) and Leukotriene C4(LTC4) in the supernatants of neutrophil suspensions after phytohemagglutinin (PHA) induced aggregation. Promazine at all concentrations decreased neutrophil function and LTC4 release.

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JO - Hematology Reviews and Communications

JF - Hematology Reviews and Communications

IS - 2

ER -

Phospholipase A₂ (PLA₂) and phenothiazines: Evidence for a correlation in blocking phagocyte function

Abstract

ASJC Scopus subject areas

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