Phase II cooperative study with a new alkylating drug, PTT-119, in the treatment of non-Hodgkin's lymphomas

F. Gherlinzoni, P. Mazza, P. L. Zinzani, S. Tura, F. Lanza, G. Castoldi, G. Bellesi, P. L. Rossi Ferrini, L. Mangoni, V. Rizzoli, P. Gobbi, E. Ascari, A. Tabilio, M. F. Martelli, A. Manna, A. Porcellini, C. Guglielmi, F. Mandelli, M. Antimi, G. PapaR. Fanin, M. Baccarani, T. Chisesi, E. Dini

Research output: Contribution to journalArticlepeer-review


In a phase II cooperative study involving eleven Italian haematological units, the efficacy and toxicity of a new alkylating compound, PTT-119, was evaluated in 53 patients with non-Hodgkin's lymphoma (NHL). Forty-five of the patients had been previously treated with various regimens of chemotherapy, the remaining eight were at the onset of the disease. PTT-119 was scheduled at 3.0 mg/kg every three weeks for a minimum of three administrations. Seven patients achieved a complete remission (CR), 19 a partial remission (PR); the overall response rate was 49%. The median duration of response was 6 months. Most frequent adverse effects were alopecia, nausea and vomiting and phlebitis due to the drug infusion. Myelosuppression was severe only in patients with bone marrow involvement or who were heavily pretreated. No liver, cardiac or renal toxicity was recorded. These data indicate that PTT-119 is an effective drug in the treatment of NHL; the matter of its non-crossresistance with other alkylating compounds warrants further studies.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
Issue number3
Publication statusPublished - Mar 1990


  • Alkylating drugs
  • Non-Hodgkin's lymphomas
  • PTT-119

ASJC Scopus subject areas

  • Hematology


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