Pharmacological improvement of large arteries properties

C. Giannattasio, M. Failla, I. Calchera, N. Grieco, L. Scandola, A. Grappiolo, G. Mancia

Research output: Contribution to journalArticlepeer-review


Arterial distensibility reflects mechanical properties of the arterial wall and have, thus a clearcut clinical relevance. This because an arterial distensibility reduction is associated with an increased pulse pressure, an increased cardiac work and a reduced diastolic vital organ perfusion. In recent years it has been demonstrated that arterial distensibility is reduced in marked and mild hypercholesterolemia, in a manner independent from arterial blood pressure values. Arterial mechanical properties are also impaired in heart failure, this leading to a further cardiac damage. This important vascular properties however, can be improved by appropriate treatment, while the time needed for that can be extremely long.

Original languageEnglish
Pages (from-to)744-751
Number of pages8
JournalPathologie Biologie
Issue number7
Publication statusPublished - 1999


  • Arterial distensibility
  • Atherosclerosis
  • Heart failure cardiovascular drug treatment
  • Hypercholesterolemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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