Pharmacokinetics of nomifensine in man

L. Vereczkey; G. Bianchetti; S. Garattini; P. L. Morselli

doi:10.1007/BF00429065

Pharmacokinetics of nomifensine in man

L. Vereczkey, G. Bianchetti, S. Garattini, P. L. Morselli

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Nomifensine pharmacokinetics were determined in healthy volunteers after the oral administration of 50 mg of the drug. Peak plasma levels of 95-177 ng/ml were attained within 1 to 4 hrs, and the apparent plasma half-lives ranged from 3.3 to 4.9 hrs. Assuming 100% bioavailability the drug has a relatively large apparent volume of distribution. From these findings it appears that the pharmacokinetics profile of nomifensine is considerably different from those of other known antidepressants. Implications for dosages schedules are discussed.

Original language	English
Pages (from-to)	225-227
Number of pages	3
Journal	Psychopharmacology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1007/BF00429065
Publication status	Published - Jan 1975

Keywords

Kinetics
Nomifensine
Plasma levels
Volunteers

ASJC Scopus subject areas

Pharmacology
Medicine(all)

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10.1007/BF00429065

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AU - Morselli, P. L.

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N2 - Nomifensine pharmacokinetics were determined in healthy volunteers after the oral administration of 50 mg of the drug. Peak plasma levels of 95-177 ng/ml were attained within 1 to 4 hrs, and the apparent plasma half-lives ranged from 3.3 to 4.9 hrs. Assuming 100% bioavailability the drug has a relatively large apparent volume of distribution. From these findings it appears that the pharmacokinetics profile of nomifensine is considerably different from those of other known antidepressants. Implications for dosages schedules are discussed.

AB - Nomifensine pharmacokinetics were determined in healthy volunteers after the oral administration of 50 mg of the drug. Peak plasma levels of 95-177 ng/ml were attained within 1 to 4 hrs, and the apparent plasma half-lives ranged from 3.3 to 4.9 hrs. Assuming 100% bioavailability the drug has a relatively large apparent volume of distribution. From these findings it appears that the pharmacokinetics profile of nomifensine is considerably different from those of other known antidepressants. Implications for dosages schedules are discussed.

KW - Kinetics

KW - Nomifensine

KW - Plasma levels

KW - Volunteers

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Pharmacokinetics of nomifensine in man

Abstract

Keywords

ASJC Scopus subject areas

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