Peter Brian Medawar and the discovery of acquired immunological tolerance

Domenico Ribatti

doi:10.1016/j.imlet.2015.07.004

Peter Brian Medawar and the discovery of acquired immunological tolerance

Domenico Ribatti

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

The immunological tolerance was described for the first time with the seminal observations made in 1945 by R.D. Owen, demonstrating that cattle dizygotic twins display red cell chimerism in adult life. F.M. Burnet and F. Fenner highlighted the Owen's discovery in their monograph "The production of Antibodies" published in 1949. In 1953, P. Medawar and his co-workers showed that tolerance can be experimentally induced in fetal mice and in chick embryos. In 1960, Medawar in recognition of the significance of his 1953 and 1956 papers was awarded the Nobel Prize in Physiology or Medicine with Burnet for their discovery of acquired immunologic tolerance.

Original language	English
Pages (from-to)	63-66
Number of pages	4
Journal	Immunology Letters
Volume	167
Issue number	2
DOIs	https://doi.org/10.1016/j.imlet.2015.07.004
Publication status	Published - Oct 1 2015

Keywords

History of medicine
Innunology
Not-self
Self
Tolerance

ASJC Scopus subject areas

Immunology
Immunology and Allergy

Access to Document

10.1016/j.imlet.2015.07.004

Cite this

@article{cb5fa10a5bac453a8cf5dec8227704bb,

title = "Peter Brian Medawar and the discovery of acquired immunological tolerance",

abstract = "The immunological tolerance was described for the first time with the seminal observations made in 1945 by R.D. Owen, demonstrating that cattle dizygotic twins display red cell chimerism in adult life. F.M. Burnet and F. Fenner highlighted the Owen's discovery in their monograph {"}The production of Antibodies{"} published in 1949. In 1953, P. Medawar and his co-workers showed that tolerance can be experimentally induced in fetal mice and in chick embryos. In 1960, Medawar in recognition of the significance of his 1953 and 1956 papers was awarded the Nobel Prize in Physiology or Medicine with Burnet for their discovery of acquired immunologic tolerance.",

keywords = "History of medicine, Innunology, Not-self, Self, Tolerance",

author = "Domenico Ribatti",

year = "2015",

month = oct,

day = "1",

doi = "10.1016/j.imlet.2015.07.004",

language = "English",

volume = "167",

pages = "63--66",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Peter Brian Medawar and the discovery of acquired immunological tolerance

AU - Ribatti, Domenico

PY - 2015/10/1

Y1 - 2015/10/1

N2 - The immunological tolerance was described for the first time with the seminal observations made in 1945 by R.D. Owen, demonstrating that cattle dizygotic twins display red cell chimerism in adult life. F.M. Burnet and F. Fenner highlighted the Owen's discovery in their monograph "The production of Antibodies" published in 1949. In 1953, P. Medawar and his co-workers showed that tolerance can be experimentally induced in fetal mice and in chick embryos. In 1960, Medawar in recognition of the significance of his 1953 and 1956 papers was awarded the Nobel Prize in Physiology or Medicine with Burnet for their discovery of acquired immunologic tolerance.

AB - The immunological tolerance was described for the first time with the seminal observations made in 1945 by R.D. Owen, demonstrating that cattle dizygotic twins display red cell chimerism in adult life. F.M. Burnet and F. Fenner highlighted the Owen's discovery in their monograph "The production of Antibodies" published in 1949. In 1953, P. Medawar and his co-workers showed that tolerance can be experimentally induced in fetal mice and in chick embryos. In 1960, Medawar in recognition of the significance of his 1953 and 1956 papers was awarded the Nobel Prize in Physiology or Medicine with Burnet for their discovery of acquired immunologic tolerance.

KW - History of medicine

KW - Innunology

KW - Not-self

KW - Self

KW - Tolerance

UR - http://www.scopus.com/inward/record.url?scp=84938948964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938948964&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2015.07.004

DO - 10.1016/j.imlet.2015.07.004

M3 - Article

C2 - 26192442

AN - SCOPUS:84938948964

SN - 0165-2478

VL - 167

SP - 63

EP - 66

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -

Peter Brian Medawar and the discovery of acquired immunological tolerance

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this