TY - JOUR
T1 - Persistent interferon-β-1b-induced psychosis in a patient with multiple sclerosis
AU - Manfredi, Giovanni
AU - Kotzalidis, Giorgio D.
AU - Sani, Gabriele
AU - Koukopoulos, Alexia E.
AU - Savoja, Valeria
AU - Lazanio, Simone
AU - Girardi, Nicoletta
AU - Tatarelli, Roberto
PY - 2010/10
Y1 - 2010/10
N2 - Interferon- is used in patients with multiple sclerosis to reduce autoimmunity; although other psychiatric side-effects are common, in contrast to interferon-alpha, psychosis has been reported only once. A patient with multiple sclerosis developed auditory hallucinations, paranoid delusions, and increased aggressiveness after 16 months of treatment with interferon-β-1b, 250 μg every other day. He responded after about one month to antipsychotic treatment, but tended to relapse upon dose reduction, and after 2 years still needs antipsychotics to control his symptoms. Because there was no change in his magnetic resonance imaging between pre- and post-treatment with interferon, we concluded that psychosis was more related to interferon treatment than to the underlying disease.
AB - Interferon- is used in patients with multiple sclerosis to reduce autoimmunity; although other psychiatric side-effects are common, in contrast to interferon-alpha, psychosis has been reported only once. A patient with multiple sclerosis developed auditory hallucinations, paranoid delusions, and increased aggressiveness after 16 months of treatment with interferon-β-1b, 250 μg every other day. He responded after about one month to antipsychotic treatment, but tended to relapse upon dose reduction, and after 2 years still needs antipsychotics to control his symptoms. Because there was no change in his magnetic resonance imaging between pre- and post-treatment with interferon, we concluded that psychosis was more related to interferon treatment than to the underlying disease.
KW - delusions
KW - hallucinations
KW - interferon-β-1b
KW - multiple sclerosis
KW - psychosis
UR - http://www.scopus.com/inward/record.url?scp=77957333559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957333559&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1819.2010.02122.x
DO - 10.1111/j.1440-1819.2010.02122.x
M3 - Article
C2 - 20939157
AN - SCOPUS:77957333559
SN - 1323-1316
VL - 64
SP - 584
EP - 586
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
IS - 5
ER -