Permissive hypofiltration: an alternative view

Zaccaria Ricci, Stefano Romagnoli, Francesco Emma

Research output: Contribution to journalArticlepeer-review


If permissive hypercapnia is used in the context of protective ventilation for patients with acute respiratory distress syndrome, it must be highlighted that the alveoli in these patients are still exposed to significant stress. Similarly, early renal replacement therapy is not necessarily a protective therapy for acute kidney injury and loop diuretics are not necessarily harmful. It is conceivable that early initiation of 'protective' low-dose (10 ml/kg/h) continuous renal replacement therapy with zero balanced ultrafiltration in association with administration of (high dose) diuretics may help to rest the kidneys while ensuring preservation of urine output.

Original languageEnglish
Article number458
JournalCritical Care
Issue number6
Publication statusPublished - Nov 8 2012

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Permissive hypofiltration: an alternative view'. Together they form a unique fingerprint.

Cite this