Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse

Raffaello Nemni; Raffaella Fazio; Massimo Corbo; Carlo Sacchi; Salvatore Smirne; Nicholas Canal

doi:10.1016/0022-510X(87)90131-6

Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse

Raffaello Nemni, Raffaella Fazio, Massimo Corbo, Carlo Sacchi, Salvatore Smirne, Nicholas Canal

Research output: Contribution to journal › Article › peer-review

Abstract

In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.

Original language	English
Pages (from-to)	321-329
Number of pages	9
Journal	Journal of the Neurological Sciences
Volume	77
Issue number	2-3
DOIs	https://doi.org/10.1016/0022-510X(87)90131-6
Publication status	Published - 1987

Keywords

Experimental neuropathy
Monoclonal gammopathy

ASJC Scopus subject areas

Ageing
Clinical Neurology
Surgery
Neuroscience(all)
Developmental Neuroscience
Neurology

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10.1016/0022-510X(87)90131-6

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abstract = "In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.",

keywords = "Experimental neuropathy, Monoclonal gammopathy",

author = "Raffaello Nemni and Raffaella Fazio and Massimo Corbo and Carlo Sacchi and Salvatore Smirne and Nicholas Canal",

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AU - Nemni, Raffaello

AU - Fazio, Raffaella

AU - Corbo, Massimo

AU - Sacchi, Carlo

AU - Smirne, Salvatore

AU - Canal, Nicholas

PY - 1987

Y1 - 1987

N2 - In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.

AB - In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.

KW - Experimental neuropathy

KW - Monoclonal gammopathy

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JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 2-3

ER -

Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse

Abstract

Keywords

ASJC Scopus subject areas

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