Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse

Raffaello Nemni, Raffaella Fazio, Massimo Corbo, Carlo Sacchi, Salvatore Smirne, Nicholas Canal

Research output: Contribution to journalArticlepeer-review


In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalJournal of the Neurological Sciences
Issue number2-3
Publication statusPublished - 1987


  • Experimental neuropathy
  • Monoclonal gammopathy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology


Dive into the research topics of 'Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse'. Together they form a unique fingerprint.

Cite this