Peripheral nervous system involvement in essential cryoglobulinemia and nephropathy

G. Valli, A. De Vecchi, L. Gaddi, E. Nobile-Orazio, A. Tarantino, S. Barbieri

Research output: Contribution to journalArticlepeer-review


The clinical and neurophysiological features of 23 patients affected by essential cryoglobulinemia (EC) have been studied. It was possible to perform sural nerve biopsy in 3 cases. Six patients were found to be affected by a peripheral neuropathy, according to the WHO criteria, while in 8 other patients clinical and neurophysiological signs of a milder peripheral nervous system (PNS) involvement were evident. The incidence of PNS involvement seems to be high (60.9%). Neurophysiological and histological studies were indicative of a mainly axonal damage.

Original languageEnglish
Pages (from-to)479-483
Number of pages5
JournalClinical and Experimental Rheumatology
Issue number5
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology
  • Rheumatology


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