Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

Francesco Autore; Nicola Piccirillo; Andrea Nozza; Idanna Innocenti; Rossana Putzulu; Patrizia Chiusolo; Federica Sora; Gina Zini; Andrea Bacigalupo; Luca Castagna; Simona Sica; Stefania Bramanti; Luca Laurenti

doi:10.1016/j.bbmt.2019.08.011

Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

Francesco Autore, Nicola Piccirillo, Andrea Nozza, Idanna Innocenti, Rossana Putzulu, Patrizia Chiusolo, Federica Sora, Gina Zini, Andrea Bacigalupo, Luca Castagna, Simona Sica, Stefania Bramanti, Luca Laurenti

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Article › peer-review

Abstract

Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.

Original language	English
Pages (from-to)	2514-2516
Number of pages	3
Journal	Biology of Blood and Marrow Transplantation
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.bbmt.2019.08.011
Publication status	Published - Dec 2019

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Autore, F., Piccirillo, N., Nozza, A., Innocenti, I., Putzulu, R., Chiusolo, P., Sora, F., Zini, G., Bacigalupo, A., Castagna, L., Sica, S., Bramanti, S., & Laurenti, L. (2019). Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers. Biology of Blood and Marrow Transplantation, 25(12), 2514-2516. https://doi.org/10.1016/j.bbmt.2019.08.011

Autore, F, Piccirillo, N, Nozza, A, Innocenti, I, Putzulu, R, Chiusolo, P, Sora, F, Zini, G, Bacigalupo, A, Castagna, L, Sica, S, Bramanti, S & Laurenti, L 2019, 'Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers', Biology of Blood and Marrow Transplantation, vol. 25, no. 12, pp. 2514-2516. https://doi.org/10.1016/j.bbmt.2019.08.011

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abstract = "Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.",

author = "Francesco Autore and Nicola Piccirillo and Andrea Nozza and Idanna Innocenti and Rossana Putzulu and Patrizia Chiusolo and Federica Sora and Gina Zini and Andrea Bacigalupo and Luca Castagna and Simona Sica and Stefania Bramanti and Luca Laurenti",

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T2 - A Retrospective Study at 2 Hematologic Italian Centers

AU - Autore, Francesco

AU - Piccirillo, Nicola

AU - Nozza, Andrea

AU - Innocenti, Idanna

AU - Putzulu, Rossana

AU - Chiusolo, Patrizia

AU - Sora, Federica

AU - Zini, Gina

AU - Bacigalupo, Andrea

AU - Castagna, Luca

AU - Sica, Simona

AU - Bramanti, Stefania

AU - Laurenti, Luca

PY - 2019/12

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N2 - Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.

AB - Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.

U2 - 10.1016/j.bbmt.2019.08.011

DO - 10.1016/j.bbmt.2019.08.011

M3 - Article

C2 - 31445184

SN - 1083-8791

VL - 25

SP - 2514

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JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 12

ER -

Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

Abstract

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