TY - JOUR
T1 - Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients
AU - Ciancarelli, Irene
AU - De Amicis, Daniela
AU - Di Massimo, Caterina
AU - Di Scanno, Carla
AU - Pistarini, Caterina
AU - D'Orazio, Nicolantonio
AU - Tozzi Ciancarelli, Maria Giuliana
PY - 2014
Y1 - 2014
N2 - Context: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD). Materials and methods: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2′-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients. Results: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed. Discussion and conclusion: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.
AB - Context: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD). Materials and methods: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2′-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients. Results: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed. Discussion and conclusion: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.
KW - Biomarkers
KW - Huntington's disease
KW - Neuronal oxidative damage
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84906350636&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906350636&partnerID=8YFLogxK
U2 - 10.3109/1354750X.2014.935955
DO - 10.3109/1354750X.2014.935955
M3 - Article
C2 - 24980251
AN - SCOPUS:84906350636
SN - 1354-750X
VL - 19
SP - 452
EP - 456
JO - Biomarkers
JF - Biomarkers
IS - 6
ER -