Periodic electroencephalogram complexes in a patient with variant Creutzfeldt-Jakob disease

Simona Binelli, Pamela Agazzi, Giorgio Giaccone, Robert G. Will, Orso Bugiani, Silvana Franceschetti, Fabrizio Tagliavini

Research output: Contribution to journalArticlepeer-review


Objective: Based on the current criteria, the diagnosis of "possible" or "probable" variant Creutzfeldt-Jakob disease (vCJD) implies the absence of periodic sharp wave complexes (PSWCs) in the electroencephalogram (EEG). To verify this point, we investigated the development of the EEG changes along the course of the disease in a pateint with vCJD. Methods: Long-lasting EEG-polygraphic recordings were performed once a month during the last year of illness. Results: We found the occurrence of a typical EEG periodic pattern in the late clinical stage of the vCJD patient. Interpretation: In the light of our finding, the diagnostic criteria for vCJD should be amended to include the possibility of a typical periodic EEG in advanced stages of disease in cases with long survival.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalAnnals of Neurology
Issue number2
Publication statusPublished - Feb 2006

ASJC Scopus subject areas

  • Neuroscience(all)


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