Percutaneous coronary intervention versus bypass surgery for left main coronary artery disease: A meta-analysis of randomised trials

Giuseppe Ferrante; Patrizia Presbitero; Marco Valgimigli; Marie Claude Morice; Paolo Pagnotta; Guido Belli; Elena Corrada; Yoshinobu Onuma; Peter Barlis; Didier Locca; Eric Eeckhout; Carlo Di Mario; Patrick W. Serruys

doi:10.4244/EIJV7I6A117

Percutaneous coronary intervention versus bypass surgery for left main coronary artery disease: A meta-analysis of randomised trials

Giuseppe Ferrante, Patrizia Presbitero, Marco Valgimigli, Marie Claude Morice, Paolo Pagnotta, Guido Belli, Elena Corrada, Yoshinobu Onuma, Peter Barlis, Didier Locca, Eric Eeckhout, Carlo Di Mario, Patrick W. Serruys

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: We performed a meta-analysis of randomised trials comparing percutaneous coronary intervention (PCI) with stent implantation to coronary artery bypass grafting (CABG) for the treatment of unprotected left main coronary artery stenosis (ULMCA). Methods and results: Pubmed and other databases were searched. Data were expressed as odds ratios (OR) with 95% confidence interval (CI). Four randomised trials enrolling 1,611 patients were selected. At 12-month follow-up PCI, as compared to CABG, was associated with a significant risk reduction of stroke (0.12% vs. 1.90%, OR 0.14, 95% CI [0.04 to 0.55], p=0.004), with an increased risk of repeat revascularisation (11.03% vs. 5.45%, OR 2.17, 95% CI [1.48 to 3.17], p

Original language	English
Pages (from-to)	738-746
Number of pages	9
Journal	EuroIntervention
Volume	7
Issue number	6
DOIs	https://doi.org/10.4244/EIJV7I6A117
Publication status	Published - Oct 2011

Keywords

Coronary artery bypass graft surgery
Left main coronary artery disease
Percutaneous coronary intervention

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.4244/EIJV7I6A117

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Ferrante, G., Presbitero, P., Valgimigli, M., Morice, M. C., Pagnotta, P., Belli, G., Corrada, E., Onuma, Y., Barlis, P., Locca, D., Eeckhout, E., Mario, C. D., & Serruys, P. W. (2011). Percutaneous coronary intervention versus bypass surgery for left main coronary artery disease: A meta-analysis of randomised trials. EuroIntervention, 7(6), 738-746. https://doi.org/10.4244/EIJV7I6A117

Ferrante, G, Presbitero, P, Valgimigli, M, Morice, MC, Pagnotta, P, Belli, G, Corrada, E, Onuma, Y, Barlis, P, Locca, D, Eeckhout, E, Mario, CD & Serruys, PW 2011, 'Percutaneous coronary intervention versus bypass surgery for left main coronary artery disease: A meta-analysis of randomised trials', EuroIntervention, vol. 7, no. 6, pp. 738-746. https://doi.org/10.4244/EIJV7I6A117

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AU - Morice, Marie Claude

AU - Pagnotta, Paolo

AU - Belli, Guido

AU - Corrada, Elena

AU - Onuma, Yoshinobu

AU - Barlis, Peter

AU - Locca, Didier

AU - Eeckhout, Eric

AU - Mario, Carlo Di

AU - Serruys, Patrick W.

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N2 - Aims: We performed a meta-analysis of randomised trials comparing percutaneous coronary intervention (PCI) with stent implantation to coronary artery bypass grafting (CABG) for the treatment of unprotected left main coronary artery stenosis (ULMCA). Methods and results: Pubmed and other databases were searched. Data were expressed as odds ratios (OR) with 95% confidence interval (CI). Four randomised trials enrolling 1,611 patients were selected. At 12-month follow-up PCI, as compared to CABG, was associated with a significant risk reduction of stroke (0.12% vs. 1.90%, OR 0.14, 95% CI [0.04 to 0.55], p=0.004), with an increased risk of repeat revascularisation (11.03% vs. 5.45%, OR 2.17, 95% CI [1.48 to 3.17], p

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KW - Percutaneous coronary intervention

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Percutaneous coronary intervention versus bypass surgery for left main coronary artery disease: A meta-analysis of randomised trials

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