TY - JOUR
T1 - Pelvic adhesion and gonadotropin-releasing hormone analogue
T2 - Effects of triptorelin acetate depot on coagulation and fibrinolytic activities
AU - Di Nardo, Maria Antonietta
AU - Annunziata, Maria Laura
AU - Ammirabile, Massimiliano
AU - Di Minno, Matteo Nicola Dario
AU - Ruocco, Anna Lilia
AU - De Falco, Marianna
AU - Di Lieto, Andrea
PY - 2012/6
Y1 - 2012/6
N2 - The study investigated the impact of gonadotropin-releasing hormone analogue (GnRH-a) on coagulation and fibrinolytic activities and its effectiveness in the prevention of pelvic adhesion after myomectomy. Thirty-two infertile women underwent myomectomy followed by adhesion evaluation surgery with a second-look laparoscopy. Before myomectomy, 15 women were treated with triptorelin acetate for 3 months and 17 received no treatment. Plasminogen activator inhibitor (PAI), thrombin activatable fibrinolysis inhibitor (TAFI), protein C (PC), plasminogen, α2-antiplasmin were determined by enzyme-linked immunosorbent assays and the activity of coagulation factors V and VIII by coagulometric methods. Patients treated with GnRH-a showed significant decrease in PAI, TAFI, factors V, and VIII (P
AB - The study investigated the impact of gonadotropin-releasing hormone analogue (GnRH-a) on coagulation and fibrinolytic activities and its effectiveness in the prevention of pelvic adhesion after myomectomy. Thirty-two infertile women underwent myomectomy followed by adhesion evaluation surgery with a second-look laparoscopy. Before myomectomy, 15 women were treated with triptorelin acetate for 3 months and 17 received no treatment. Plasminogen activator inhibitor (PAI), thrombin activatable fibrinolysis inhibitor (TAFI), protein C (PC), plasminogen, α2-antiplasmin were determined by enzyme-linked immunosorbent assays and the activity of coagulation factors V and VIII by coagulometric methods. Patients treated with GnRH-a showed significant decrease in PAI, TAFI, factors V, and VIII (P
KW - coagulation system
KW - fibrinolytic system
KW - gonadotropin-releasing hormone analogue
KW - myomectomy
KW - pelvic adhesion
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U2 - 10.1177/1933719111428517
DO - 10.1177/1933719111428517
M3 - Article
C2 - 22344729
AN - SCOPUS:84862849198
SN - 1933-7191
VL - 19
SP - 615
EP - 622
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 6
ER -