Pediatric cerebral stroke induced by epstein-barr virus infection: Role of interleukin overexpression

Antonio Gatto, Serenella Angelici, Marzia Soligo, Daniela Di Giuda, Luigi Manni, Antonietta Curatola, Serena Ferretti, Antonio Chiaretti

Research output: Contribution to journalArticlepeer-review


Introduction: Ischemic stroke is an important cause of death and long-term morbidity in children. Viral respiratory infections are emerging as important risk factors for ischemic stroke in this age group of patients. Direct action of virus against cerebral vessels, autoimmune reactivity, and an increased production of cytokines have all been advocated as main factors in determining ischemic stroke. Case Report: We report the case of an EBV-induced ischemic stroke in a caucasian 2-year-old female. The cerebrospinal fluid samples showed positivity of polymerase chain reaction for EBV infection, also confirmed by pharyngeal swab culture. Increased levels of interleukin 6 and interleukin 1β were also detected in the cerebrospinal fluid. Discussion: EBV infection has been identified as an important cause of neurological involvement in children. Findings of increased levels of interleukin 6 and interleukin 1β in the cerebrospinal fluid of the child with EBV inducedischemic stroke seems to validate the role of pro-inflammatory cytokines as crucial mediators of cerebral thrombus formation. Conclusions: We believe that this report can be useful to clarify some pathophysiological mechanisms related to ischemic stroke related to Epstein-Barr Virus (EBV) infection in children. (www.

Original languageEnglish
Article numbere2021135
JournalActa Biomedica
Issue numberS1
Publication statusPublished - Apr 30 2021


  • Cerebral stroke
  • Children
  • Epstein-barr virus
  • Interleukins
  • Personalized medicine

ASJC Scopus subject areas

  • Medicine(all)


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