PDGFB hypomethylation is a favourable prognostic biomarker in primary myelofibrosis

Claudia Augello; Umberto Gianelli; Rossella Falcone; Silvia Tabano; Federica Savi; Eleonora Bonaparte; Michele Ciboddo; Leda Paganini; Antonina Parafioriti; Dario Ricca; Silvia Lonati; Daniele Cattaneo; Nicola Stefano Fracchiolla; Alessandra Iurlo; Agostino Cortelezzi; Silvano Bosari; Monica Miozzo; Silvia Maria Sirchia

doi:10.1016/j.leukres.2014.11.012

PDGFB hypomethylation is a favourable prognostic biomarker in primary myelofibrosis

Claudia Augello, Umberto Gianelli, Rossella Falcone, Silvia Tabano, Federica Savi, Eleonora Bonaparte, Michele Ciboddo, Leda Paganini, Antonina Parafioriti, Dario Ricca, Silvia Lonati, Daniele Cattaneo, Nicola Stefano Fracchiolla, Alessandra Iurlo, Agostino Cortelezzi, Silvano Bosari, Monica Miozzo, Silvia Maria Sirchia

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterised by the clonal proliferation of the haematopoietic precursors together with the progressive development of bone marrow fibrosis. This stromal alteration is an important clinical issue and specific prognostic markers are not currently available. In bone marrow biopsies from 58 PMF patients, we explored the methylation pattern of genes encoding cytokines involved in the stromal reaction, namely platelet-derived growth factor-beta (PDGFB), transforming growth factor-beta (TGFB) and basic fibroblast growth factor (FGF2). We also evaluated the methylation profile of the Long Interspersed Nucleotide Element 1 (LINE-1). PDGFB, FGF2 and LINE-1, but not TGFB, were significantly differently methylated in PMF compared to controls. Significantly, PDGFB hypomethylation (

Original language	English
Pages (from-to)	236-241
Number of pages	6
Journal	Leukemia Research
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2014.11.012
Publication status	Published - Feb 1 2015

Keywords

DNA methylation
FGF2
LINE-1
PDGFB
Primary myelofibrosis

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology
Medicine(all)

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10.1016/j.leukres.2014.11.012

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Augello, C., Gianelli, U., Falcone, R., Tabano, S., Savi, F., Bonaparte, E., Ciboddo, M., Paganini, L., Parafioriti, A., Ricca, D., Lonati, S., Cattaneo, D., Fracchiolla, N. S., Iurlo, A., Cortelezzi, A., Bosari, S., Miozzo, M., & Sirchia, S. M. (2015). PDGFB hypomethylation is a favourable prognostic biomarker in primary myelofibrosis. Leukemia Research, 39(2), 236-241. https://doi.org/10.1016/j.leukres.2014.11.012

Augello, C, Gianelli, U, Falcone, R, Tabano, S, Savi, F, Bonaparte, E, Ciboddo, M, Paganini, L, Parafioriti, A, Ricca, D, Lonati, S, Cattaneo, D, Fracchiolla, NS , Iurlo, A, Cortelezzi, A, Bosari, S, Miozzo, M & Sirchia, SM 2015, 'PDGFB hypomethylation is a favourable prognostic biomarker in primary myelofibrosis', Leukemia Research, vol. 39, no. 2, pp. 236-241. https://doi.org/10.1016/j.leukres.2014.11.012

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abstract = "Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterised by the clonal proliferation of the haematopoietic precursors together with the progressive development of bone marrow fibrosis. This stromal alteration is an important clinical issue and specific prognostic markers are not currently available. In bone marrow biopsies from 58 PMF patients, we explored the methylation pattern of genes encoding cytokines involved in the stromal reaction, namely platelet-derived growth factor-beta (PDGFB), transforming growth factor-beta (TGFB) and basic fibroblast growth factor (FGF2). We also evaluated the methylation profile of the Long Interspersed Nucleotide Element 1 (LINE-1). PDGFB, FGF2 and LINE-1, but not TGFB, were significantly differently methylated in PMF compared to controls. Significantly, PDGFB hypomethylation (",

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AU - Augello, Claudia

AU - Gianelli, Umberto

AU - Falcone, Rossella

AU - Tabano, Silvia

AU - Savi, Federica

AU - Bonaparte, Eleonora

AU - Ciboddo, Michele

AU - Paganini, Leda

AU - Parafioriti, Antonina

AU - Ricca, Dario

AU - Lonati, Silvia

AU - Cattaneo, Daniele

AU - Fracchiolla, Nicola Stefano

AU - Iurlo, Alessandra

AU - Cortelezzi, Agostino

AU - Bosari, Silvano

AU - Miozzo, Monica

AU - Sirchia, Silvia Maria

PY - 2015/2/1

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N2 - Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterised by the clonal proliferation of the haematopoietic precursors together with the progressive development of bone marrow fibrosis. This stromal alteration is an important clinical issue and specific prognostic markers are not currently available. In bone marrow biopsies from 58 PMF patients, we explored the methylation pattern of genes encoding cytokines involved in the stromal reaction, namely platelet-derived growth factor-beta (PDGFB), transforming growth factor-beta (TGFB) and basic fibroblast growth factor (FGF2). We also evaluated the methylation profile of the Long Interspersed Nucleotide Element 1 (LINE-1). PDGFB, FGF2 and LINE-1, but not TGFB, were significantly differently methylated in PMF compared to controls. Significantly, PDGFB hypomethylation (

AB - Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterised by the clonal proliferation of the haematopoietic precursors together with the progressive development of bone marrow fibrosis. This stromal alteration is an important clinical issue and specific prognostic markers are not currently available. In bone marrow biopsies from 58 PMF patients, we explored the methylation pattern of genes encoding cytokines involved in the stromal reaction, namely platelet-derived growth factor-beta (PDGFB), transforming growth factor-beta (TGFB) and basic fibroblast growth factor (FGF2). We also evaluated the methylation profile of the Long Interspersed Nucleotide Element 1 (LINE-1). PDGFB, FGF2 and LINE-1, but not TGFB, were significantly differently methylated in PMF compared to controls. Significantly, PDGFB hypomethylation (

KW - DNA methylation

KW - FGF2

KW - LINE-1

KW - PDGFB

KW - Primary myelofibrosis

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PDGFB hypomethylation is a favourable prognostic biomarker in primary myelofibrosis

Abstract

Keywords

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