PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases: Liver International

V. De Re; M.L. Tornesello; M. De Zorzi; L. Caggiari; F. Pezzuto; P. Leone; V. Racanelli; G. Lauletta; S. Zanussi; O. Repetto; L. Gragnani; F.M. Rossi; R. Dolcetti; A.L. Zignego; F.M. Buonaguro; A. Steffan

doi:10.1111/liv.14667

PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases: Liver International

V. De Re, M.L. Tornesello, M. De Zorzi, L. Caggiari, F. Pezzuto, P. Leone, V. Racanelli, G. Lauletta, S. Zanussi, O. Repetto, L. Gragnani, F.M. Rossi, R. Dolcetti, A.L. Zignego, F.M. Buonaguro, A. Steffan

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Genetic variants of IFNL4 and PDCD1 genes have been shown to influence the spontaneous clearance of hepatitis C virus (HCV) infection. We investigated the IFNL4 rs12979860 and the PDCD1 polymorphisms in 734 HCV-positive patients, including 461 cases with liver disease of varying severity and 273 patients with lymphoproliferative disorders to determine the association of these genes with patient's outcome. Methods: Expression levels of PDCD1 mRNA encoded by haplotypes were investigated by quantitative PCR in hepatocellular carcinoma (HCC) tissue and peripheral blood mononuclear cells. Flow cytometry was used to detect PD-1 and its ligand PD-L1. Results: The frequency of IFNL4 rs12979860 C/T or T/T genotypes was significantly higher in patients with HCV-related diseases than blood donors (P

Original language	English
Pages (from-to)	133-149
Number of pages	17
Journal	Liver Int.
Volume	41
Issue number	1
DOIs	https://doi.org/10.1111/liv.14667
Publication status	Published - 2021

Keywords

cryoglobulinaemia
hepatitis virus C
hepatocellular carcinoma
IFNλ4
PD-1
antivirus agent
CD19 antigen
immunoglobulin M
interferon
interferon lambda 4
messenger RNA
programmed death 1 ligand 1
programmed death 1 receptor
unclassified drug
virus RNA
adult
aged
allele
amino acid sequence
antiviral therapy
Article
B lymphocyte
blood donor
cancer tissue
case control study
CD4+ T lymphocyte
cell interaction
chronic hepatitis C
clinical outcome
controlled study
cryoglobulinemia
cytokine release
disease severity
epistasis
female
flow cytometry
gene frequency
gene linkage disequilibrium
gene mutation
genetic association
genetic risk
genetic susceptibility
genetic variability
genotype
haplotype
Hepatitis C virus
human
human cell
liver cell carcinoma
liver cirrhosis
liver disease
liver fibrosis
major clinical study
male
middle aged
mRNA expression level
mutational analysis
nonhodgkin lymphoma
peripheral blood mononuclear cell
real time polymerase chain reaction
regulatory B lymphocyte
single nucleotide polymorphism

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10.1111/liv.14667

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098264376&doi=10.1111%2fliv.14667&partnerID=40&md5=8c00abd664104cf4ede82ed14d8c5c9c

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De Re, V., Tornesello, M. L., De Zorzi, M., Caggiari, L., Pezzuto, F., Leone, P., Racanelli, V., Lauletta, G., Zanussi, S., Repetto, O., Gragnani, L., Rossi, F. M., Dolcetti, R., Zignego, A. L., Buonaguro, F. M., & Steffan, A. (2021). PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases: Liver International. Liver Int., 41(1), 133-149. https://doi.org/10.1111/liv.14667

De Re, V , Tornesello, ML , De Zorzi, M , Caggiari, L, Pezzuto, F, Leone, P, Racanelli, V, Lauletta, G, Zanussi, S , Repetto, O, Gragnani, L, Rossi, FM, Dolcetti, R, Zignego, AL, Buonaguro, FM & Steffan, A 2021, 'PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases: Liver International', Liver Int., vol. 41, no. 1, pp. 133-149. https://doi.org/10.1111/liv.14667

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title = "PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases: Liver International",

abstract = "Background: Genetic variants of IFNL4 and PDCD1 genes have been shown to influence the spontaneous clearance of hepatitis C virus (HCV) infection. We investigated the IFNL4 rs12979860 and the PDCD1 polymorphisms in 734 HCV-positive patients, including 461 cases with liver disease of varying severity and 273 patients with lymphoproliferative disorders to determine the association of these genes with patient's outcome. Methods: Expression levels of PDCD1 mRNA encoded by haplotypes were investigated by quantitative PCR in hepatocellular carcinoma (HCC) tissue and peripheral blood mononuclear cells. Flow cytometry was used to detect PD-1 and its ligand PD-L1. Results: The frequency of IFNL4 rs12979860 C/T or T/T genotypes was significantly higher in patients with HCV-related diseases than blood donors (P ",

keywords = "cryoglobulinaemia, hepatitis virus C, hepatocellular carcinoma, IFNλ4, PD-1, antivirus agent, CD19 antigen, immunoglobulin M, interferon, interferon lambda 4, messenger RNA, programmed death 1 ligand 1, programmed death 1 receptor, unclassified drug, virus RNA, adult, aged, allele, amino acid sequence, antiviral therapy, Article, B lymphocyte, blood donor, cancer tissue, case control study, CD4+ T lymphocyte, cell interaction, chronic hepatitis C, clinical outcome, controlled study, cryoglobulinemia, cytokine release, disease severity, epistasis, female, flow cytometry, gene frequency, gene linkage disequilibrium, gene mutation, genetic association, genetic risk, genetic susceptibility, genetic variability, genotype, haplotype, Hepatitis C virus, human, human cell, liver cell carcinoma, liver cirrhosis, liver disease, liver fibrosis, major clinical study, male, middle aged, mRNA expression level, mutational analysis, nonhodgkin lymphoma, peripheral blood mononuclear cell, real time polymerase chain reaction, regulatory B lymphocyte, single nucleotide polymorphism",

author = "{De Re}, V. and M.L. Tornesello and {De Zorzi}, M. and L. Caggiari and F. Pezzuto and P. Leone and V. Racanelli and G. Lauletta and S. Zanussi and O. Repetto and L. Gragnani and F.M. Rossi and R. Dolcetti and A.L. Zignego and F.M. Buonaguro and A. Steffan",

note = "Cited By :3 Export Date: 8 February 2022 CODEN: LIINC Correspondence Address: De Re, V.; Immunopathology and Cancer Biomarkers/Bioproteomic facility, Italy; email: vdere@cro.it",

year = "2021",

doi = "10.1111/liv.14667",

language = "English",

volume = "41",

pages = "133--149",

journal = "Liver Int.",

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TY - JOUR

T1 - PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases

T2 - Liver International

AU - De Re, V.

AU - Tornesello, M.L.

AU - De Zorzi, M.

AU - Caggiari, L.

AU - Pezzuto, F.

AU - Leone, P.

AU - Racanelli, V.

AU - Lauletta, G.

AU - Zanussi, S.

AU - Repetto, O.

AU - Gragnani, L.

AU - Rossi, F.M.

AU - Dolcetti, R.

AU - Zignego, A.L.

AU - Buonaguro, F.M.

AU - Steffan, A.

N1 - Cited By :3 Export Date: 8 February 2022 CODEN: LIINC Correspondence Address: De Re, V.; Immunopathology and Cancer Biomarkers/Bioproteomic facility, Italy; email: vdere@cro.it

PY - 2021

Y1 - 2021

N2 - Background: Genetic variants of IFNL4 and PDCD1 genes have been shown to influence the spontaneous clearance of hepatitis C virus (HCV) infection. We investigated the IFNL4 rs12979860 and the PDCD1 polymorphisms in 734 HCV-positive patients, including 461 cases with liver disease of varying severity and 273 patients with lymphoproliferative disorders to determine the association of these genes with patient's outcome. Methods: Expression levels of PDCD1 mRNA encoded by haplotypes were investigated by quantitative PCR in hepatocellular carcinoma (HCC) tissue and peripheral blood mononuclear cells. Flow cytometry was used to detect PD-1 and its ligand PD-L1. Results: The frequency of IFNL4 rs12979860 C/T or T/T genotypes was significantly higher in patients with HCV-related diseases than blood donors (P

AB - Background: Genetic variants of IFNL4 and PDCD1 genes have been shown to influence the spontaneous clearance of hepatitis C virus (HCV) infection. We investigated the IFNL4 rs12979860 and the PDCD1 polymorphisms in 734 HCV-positive patients, including 461 cases with liver disease of varying severity and 273 patients with lymphoproliferative disorders to determine the association of these genes with patient's outcome. Methods: Expression levels of PDCD1 mRNA encoded by haplotypes were investigated by quantitative PCR in hepatocellular carcinoma (HCC) tissue and peripheral blood mononuclear cells. Flow cytometry was used to detect PD-1 and its ligand PD-L1. Results: The frequency of IFNL4 rs12979860 C/T or T/T genotypes was significantly higher in patients with HCV-related diseases than blood donors (P

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KW - cytokine release

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KW - female

KW - flow cytometry

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KW - liver fibrosis

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KW - mRNA expression level

KW - mutational analysis

KW - nonhodgkin lymphoma

KW - peripheral blood mononuclear cell

KW - real time polymerase chain reaction

KW - regulatory B lymphocyte

KW - single nucleotide polymorphism

U2 - 10.1111/liv.14667

DO - 10.1111/liv.14667

M3 - Article

SN - 1478-3223

VL - 41

SP - 133

EP - 149

JO - Liver Int.

JF - Liver Int.

IS - 1

ER -

PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus-related diseases: Liver International

Abstract

Keywords

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