Pathological classification of DCIS and planning of therapeutic management

Oreste Claudio Buonomo; P. Orsaria; G. Contino; D. Varvaras; A. Gioia; E. Bonanno; C. Pistolese; E. Cossu; T. Perretta; O. Schillaci; G. Del Monte; M. Roselli; T. C. Mineo; G. Petrella

Pathological classification of DCIS and planning of therapeutic management

Oreste Claudio Buonomo, P. Orsaria, G. Contino, D. Varvaras, A. Gioia, E. Bonanno, C. Pistolese, E. Cossu, T. Perretta, O. Schillaci, G. Del Monte, M. Roselli, T. C. Mineo, G. Petrella

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Abstract

Background: Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3. The aim of the study was to asses the correlation between the DIN classification and the surgical treatment including sentinel lymph node biopsy (SLNB). Patients and Methods: In this retrospective study, 229 patients with DIN had undergone conservative or radical surgical treatment and SLNB in cases of DIN1C-DIN3. Results: Breast conservative surgery was the definitive treatment in 80% of the cases. The H&E evaluation of excised sentinel nodes was negative for metastatic disease; neverthless the immunohistochemical (IHC) evaluation revealed the presence of metastatic cells in 6 patients (3.7%). Conclusion: In cases of DIN lesions SLNB is not indicated. The only reason SLNB should be considered is when there is an evidence of invasive foci at definitive histology or when radical mastectomy is proposed.

Original language	English
Pages (from-to)	1499-1506
Number of pages	8
Journal	Anticancer Research
Volume	29
Issue number	5
Publication status	Published - May 2009

Keywords

Breast cancer
Ductal in situ carcinoma
Lymph node
Sentinel node biopsy

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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title = "Pathological classification of DCIS and planning of therapeutic management",

abstract = "Background: Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3. The aim of the study was to asses the correlation between the DIN classification and the surgical treatment including sentinel lymph node biopsy (SLNB). Patients and Methods: In this retrospective study, 229 patients with DIN had undergone conservative or radical surgical treatment and SLNB in cases of DIN1C-DIN3. Results: Breast conservative surgery was the definitive treatment in 80% of the cases. The H&E evaluation of excised sentinel nodes was negative for metastatic disease; neverthless the immunohistochemical (IHC) evaluation revealed the presence of metastatic cells in 6 patients (3.7%). Conclusion: In cases of DIN lesions SLNB is not indicated. The only reason SLNB should be considered is when there is an evidence of invasive foci at definitive histology or when radical mastectomy is proposed.",

keywords = "Breast cancer, Ductal in situ carcinoma, Lymph node, Sentinel node biopsy",

author = "Buonomo, {Oreste Claudio} and P. Orsaria and G. Contino and D. Varvaras and A. Gioia and E. Bonanno and C. Pistolese and E. Cossu and T. Perretta and O. Schillaci and {Del Monte}, G. and M. Roselli and Mineo, {T. C.} and G. Petrella",

year = "2009",

month = may,

language = "English",

volume = "29",

pages = "1499--1506",

journal = "Anticancer Research",

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TY - JOUR

T1 - Pathological classification of DCIS and planning of therapeutic management

AU - Buonomo, Oreste Claudio

AU - Orsaria, P.

AU - Contino, G.

AU - Varvaras, D.

AU - Gioia, A.

AU - Bonanno, E.

AU - Pistolese, C.

AU - Cossu, E.

AU - Perretta, T.

AU - Schillaci, O.

AU - Del Monte, G.

AU - Roselli, M.

AU - Mineo, T. C.

AU - Petrella, G.

PY - 2009/5

Y1 - 2009/5

N2 - Background: Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3. The aim of the study was to asses the correlation between the DIN classification and the surgical treatment including sentinel lymph node biopsy (SLNB). Patients and Methods: In this retrospective study, 229 patients with DIN had undergone conservative or radical surgical treatment and SLNB in cases of DIN1C-DIN3. Results: Breast conservative surgery was the definitive treatment in 80% of the cases. The H&E evaluation of excised sentinel nodes was negative for metastatic disease; neverthless the immunohistochemical (IHC) evaluation revealed the presence of metastatic cells in 6 patients (3.7%). Conclusion: In cases of DIN lesions SLNB is not indicated. The only reason SLNB should be considered is when there is an evidence of invasive foci at definitive histology or when radical mastectomy is proposed.

AB - Background: Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3. The aim of the study was to asses the correlation between the DIN classification and the surgical treatment including sentinel lymph node biopsy (SLNB). Patients and Methods: In this retrospective study, 229 patients with DIN had undergone conservative or radical surgical treatment and SLNB in cases of DIN1C-DIN3. Results: Breast conservative surgery was the definitive treatment in 80% of the cases. The H&E evaluation of excised sentinel nodes was negative for metastatic disease; neverthless the immunohistochemical (IHC) evaluation revealed the presence of metastatic cells in 6 patients (3.7%). Conclusion: In cases of DIN lesions SLNB is not indicated. The only reason SLNB should be considered is when there is an evidence of invasive foci at definitive histology or when radical mastectomy is proposed.

KW - Breast cancer

KW - Ductal in situ carcinoma

KW - Lymph node

KW - Sentinel node biopsy

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Pathological classification of DCIS and planning of therapeutic management

Abstract

Keywords

ASJC Scopus subject areas

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