Pathogenesis of type I (insulin-dependent) diabetes: Possible mechanisms of autoimmune damage

G. F. Bottazzo, E. Bosi, E. Bonifacio, R. Mirakian, I. Todd, R. Pujol-Borrell

Research output: Contribution to journalArticlepeer-review


By definition, autoimmunity is a circumvention of self-tolerance. Considering the complex network of control mechanisms which initiate and regulate immune responses to foreign agents and maintain the natural state of self-tolerance, autoimmunity may result from a weakening of this delicate equilibrium at various levels. Several hypotheses have therefore been put forward to explain the 'active' immunization process against self-constituents which are normally tolerated.

Original languageEnglish
Pages (from-to)37-57
Number of pages21
JournalBritish Medical Bulletin
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Medicine(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)


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