Pathogenesis of "de novo" cavernous malformations: A case report and review of the literature

F. De Santis, R. Agati, L. Simonetti

Research output: Contribution to journalArticlepeer-review


Cavernous malformations are vascular lesions presenting histologically as a collection of blood-filled spaces separated by a loose connective tissue network. Cavernous malformations may be familial or sporadic, both forms having a prevalence of around 0.5%. They account for between 8% and 15% of all cerebrovascular malformations, but are responsible for a disproportionately high percentage of symptoms. Although specific histological markers can distinguish different cerebrovascular malformations, there exist "mixed" lesions presenting histological features common to different forms, thereby giving rise to different theories as to the pathogenesis of cavernous malformations. We describe a young woman with a previously undetected lesion in the right temporal lobe revealed during follow-up MR investigation after resection of a skull base tumour. The lesion presented the typical MR features of cavernous malformation. The literature on the topic is reviewed, discussing the different pathogenetic hypotheses for "de novo" cavernous malformations.

Original languageEnglish
Pages (from-to)445-452
Number of pages8
JournalRivista di Neuroradiologia
Issue number4
Publication statusPublished - 2001


  • Cavernous malformation
  • Radiotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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