TY - JOUR
T1 - Parent psychopathology and offspring mental disorders
T2 - Results from the WHO World Mental Health Surveys
AU - McLaughlin, Katie A.
AU - Gadermann, Anne M.
AU - Hwang, Irving
AU - Sampson, Nancy A.
AU - Al-Hamzawi, Ali
AU - Andrade, Laura Helena
AU - Angermeyer, Matthias C.
AU - Benjet, Corina
AU - Bromet, Evelyn J.
AU - Bruffaerts, Ronny
AU - Caldas-de-Almeida, José Miguel
AU - De Girolamo, Giovanni
AU - De Graaf, Ron
AU - Florescu, Silvia
AU - Gureje, Oye
AU - Haro, Josep Maria
AU - Hinkov, Hristo Ruskov
AU - Horiguchi, Itsuko
AU - Hu, Chiyi
AU - Karam, Aimee Nasser
AU - Kovess-Masfety, Viviane
AU - Lee, Sing
AU - Murphy, Samuel D.
AU - Nizamie, S. Haque
AU - Posada-Villa, José
AU - Williams, David R.
AU - Kessler, Ronald C.
PY - 2012/4
Y1 - 2012/4
N2 - Background: Associations between specific parent and offspring mental disorders are likely to have been overestimated in studies that have failed to control for parent comorbidity. Aims: To examine the associations of parent with respondent disorders. Method: Data come from the World Health Organization (WHO) World Mental Health Surveys (n = 51 507). Respondent disorders were assessed with the Composite International Diagnostic Interview and parent disorders with informant-based Family History Research Diagnostic Criteria interviews. Results: Although virtually all parent disorders examined (major depressive, generalised anxiety, panic, substance and antisocial behaviour disorders and suicidality) were significantly associated with offspring disorders in multivariate analyses, little specificity was found. Comorbid parent disorders had significant sub-additive associations with offspring disorders. Population-attributable risk proportions for parent disorders were 12.4% across all offspring disorders, generally higher in high- and upper-middle-than low-/lower-middle-income countries, and consistently higher for behaviour (11.0-19.9%) than other (7.1-14.0%) disorders. Conclusions: Parent psychopathology is a robust non-specific predictor associated with a substantial proportion of offspring disorders.
AB - Background: Associations between specific parent and offspring mental disorders are likely to have been overestimated in studies that have failed to control for parent comorbidity. Aims: To examine the associations of parent with respondent disorders. Method: Data come from the World Health Organization (WHO) World Mental Health Surveys (n = 51 507). Respondent disorders were assessed with the Composite International Diagnostic Interview and parent disorders with informant-based Family History Research Diagnostic Criteria interviews. Results: Although virtually all parent disorders examined (major depressive, generalised anxiety, panic, substance and antisocial behaviour disorders and suicidality) were significantly associated with offspring disorders in multivariate analyses, little specificity was found. Comorbid parent disorders had significant sub-additive associations with offspring disorders. Population-attributable risk proportions for parent disorders were 12.4% across all offspring disorders, generally higher in high- and upper-middle-than low-/lower-middle-income countries, and consistently higher for behaviour (11.0-19.9%) than other (7.1-14.0%) disorders. Conclusions: Parent psychopathology is a robust non-specific predictor associated with a substantial proportion of offspring disorders.
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U2 - 10.1192/bjp.bp.111.101253
DO - 10.1192/bjp.bp.111.101253
M3 - Article
C2 - 22403085
AN - SCOPUS:84859600597
SN - 0007-1250
VL - 200
SP - 290
EP - 299
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 4
ER -