Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

Massimo Luca Castellazzi, Samantha Bosis, Irene Borzani, Claudia Tagliabue, Raffaella Pinzani, Paola Marchisio, Giada Maria di Pietro

Research output: Contribution to journalArticlepeer-review


Background: Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. A literature review starting from 2010 was also performed in order to discuss clinical presentations, radiological findings, treatment and outcome. Case presentation: This is a case of a 6-month-old boy who rapidly developed high fever and poor general condition. He was diagnosed as having multiple muscular abscesses, multiple foci of osteomyelitis and bloodstream infections caused by Panton-Valentine leukocidin Methicillin-resistant Staphylococcus aureus. He received intravenous antibiotics and surgical drainage of the abscess with progressive recovery. Conclusion: Our report highlights the importance of improving awareness of this severe infection, as a prompt diagnosis and adequate manage is essential in order to save life and to prevent serious complications.

Original languageEnglish
Article number158
JournalItalian Journal of Pediatrics
Issue number1
Publication statusPublished - Dec 2021


  • Children
  • Infection
  • Panton-valentine leukocidin
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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