Overweight Patients Operated on for Cancer of the Esophagus Survive Longer than Normal-Weight Patients

Marco Scarpa, Matteo Cagol, Silvia Bettini, Rita Alfieri, Amedeo Carraro, Francesco Cavallin, Elisabetta Trevellin, Luca M. Saadeh, Alberto Ruol, Roberto Vettor, Ermanno Ancona, Carlo Castoro

Research output: Contribution to journalArticlepeer-review


Background: Esophageal adenocarcinoma is often associated with obesity, and a 5 Kg m-2 increase in body mass index (BMI) has, in fact, been found to be strongly associated with the risk of this type of cancer (RR, 1.52; p <0.0001). Esophagectomy with lymphoadenectomy is the mainstay of therapy for these patients. The aim of this study was to assess and compare the surgical and oncological outcomes as well as the survival rates of underweight, normal weight, overweight, and obese patients following esophagectomy for esophageal cancer. Patients and Methods: Data relative to 1,127 patients with esophageal adenocarcinoma presenting at a specialized tertiary hospital (the Center of Esophageal Diseases for the Veneto Region) between 2000 and 2008 were prospectively collected. The 278 subjects whose BMI values before disease onset were available and underwent esophagectomy were enrolled in the study. Sixty-one of the 278 patients were classified as obese (BMI >30), 121 were classified as overweight (BMI, 25-29.9), 81 were classified as normal weight (BMI

Original languageEnglish
Pages (from-to)218-227
Number of pages10
JournalJournal of Gastrointestinal Surgery
Issue number2
Publication statusPublished - 2013


  • BMI
  • Esophageal cancer
  • Esophagectomy
  • Obesity

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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