Overview and potential unifying themes of the atypical chemokine receptor family

Alessandro Vacchini, Massimo Locati, Elena Monica Borroni

Research output: Contribution to journalReview articlepeer-review


Chemokines modulate immune responses through their ability to orchestrate the migration of target cells. Chemokines directly induce cell migration through a distinct set of 7 transmembrane domain G proteincoupled receptors but are also recognized by a small subfamily of atypical chemokine receptors, characterizedby their inability to support chemotactic activity. Atypical chemokine receptors are now emerging as crucial regulatory components of chemokine networks in a wide range of physiologic and pathologic contexts. Although a new nomenclature has been approved recently to reflect their functional distinction from their conventional counterparts, a systematic view of this subfamily is still missing. This review discusses their biochemical and immunologic properties to identify potential unifying themes in this emerging family.

Original languageEnglish
Pages (from-to)883-892
Number of pages10
JournalJournal of Leukocyte Biology
Issue number6
Publication statusPublished - Jun 1 2016


  • B-arrestin
  • G protein coupled receptor
  • Signaling
  • Trafficking

ASJC Scopus subject areas

  • Cell Biology
  • Immunology


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