Overexpression of human NOX1 complex induces genome instability in mammalian cells

Medicine & Life Sciences

• Genomic Instability 100%
• Reactive Oxygen Species 72%
• DNA Mismatch Repair 54%
• HeLa Cells 45%
• DNA Damage 39%
• Fibroblasts 33%
• Oxidative Stress 33%
• 8-hydroxyguanine 33%
• DNA Repair Enzymes 31%
• Hypoxanthine Phosphoribosyltransferase 31%
• Reactive Nitrogen Species 29%
• 3-nitrotyrosine 29%
• NADPH Oxidases 26%
• DNA 25%
• Mutation Rate 24%
• DNA Repair 21%
• Embryonic Structures 18%
• Clone Cells 18%
• Phenotype 13%
• Antibodies 12%
• Genes 9%
• Proteins 8%

Chemical Compounds

• Mammalian Cell 94%
• Reactive Oxygen Metabolite 85%
• Oxidative Stress 45%
• Mutagenic Agent 36%
• Reactive Nitrogen Species 31%
• Cofactor 20%
• Macromolecule 19%
• Mutation 19%
• Protein 9%