Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis

SH Yoon, S Bleiziffer, O De Backer, V Delgado, T Arai, J Ziegelmueller, M Barbanti, R Sharma, GY Perlman, OK Khalique, EW Holy, S Saraf, F Deuschl, B Fujita, P Ruile, FJ Neumann, G Pache, M Takahashi, H Kaneko, T SchmidtY Ohno, N Schofer, WKF Kong, E Tay, D Sugiyama, H Kawamori, Y Maeno, Y Abramowitz, T Chakravarty, M Nakamura, S Kuwata, G Yong, HL Kao, M Lee, HS Kim, T Modine, SC Wong, F Bedgoni, L Testa, E Teiger, C Butter, SM Ensminger, U Schaefer, D Dvir, P Blanke, J Leipsic, F Nietlispach, M Abdel-Wahab, B Chevalier, C Tamburino, D Hildick-Smith, BK Whisenant, SJ Park, A Colombo, A Latib, SK Kodali, JJ Bax, L Søndergaard, JG Webb, T Lefèvre, MB Leon, R Makkar

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Background Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with bicuspid aortic valve stenosis (AS). Objectives This study sought to compare the procedural and clinical outcomes in patients with bicuspid versus tricuspid AS from the Bicuspid AS TAVR multicenter registry. Methods Outcomes of 561 patients with bicuspid AS and 4,546 patients with tricuspid AS were compared after propensity score matching, assembling 546 pairs of patients with similar baseline characteristics. Procedural and clinical outcomes were recorded according to Valve Academic Research Consortium-2 criteria. Results Compared with patients with tricuspid AS, patients with bicuspid AS had more frequent conversion to surgery (2.0% vs. 0.2%; p = 0.006) and a significantly lower device success rate (85.3% vs. 91.4%; p = 0.002). Early-generation devices were implanted in 320 patients with bicuspid and 321 patients with tricuspid AS, whereas new-generation devices were implanted in 226 and 225 patients with bicuspid and tricuspid AS, respectively. Within the group receiving early-generation devices, bicuspid AS had more frequent aortic root injury (4.5% vs. 0.0%; p = 0.015) when receiving the balloon-expanding device, and moderate-to-severe paravalvular leak (19.4% vs. 10.5%; p = 0.02) when receiving the self-expanding device. Among patients with new-generation devices, however, procedural results were comparable across different prostheses. The cumulative all-cause mortality rates at 2 years were comparable between bicuspid and tricuspid AS (17.2% vs. 19.4%; p = 0.28). Conclusions Compared with tricuspid AS, TAVR in bicuspid AS was associated with a similar prognosis, but lower device success rate. Procedural differences were observed in patients treated with the early-generation devices, whereas no differences were observed with the new-generation devices. © 2017 The Authors
Original languageEnglish
Pages (from-to)2579-2589
Number of pages11
JournalJournal of the American College of Cardiology
Issue number21
Publication statusPublished - 2017


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