Outcome of hepatic amebic abscesses managed with three different therapeutic strategies

Carlo Filice, Giovanni Di Perri, Maurizio Strosselli, Enrico Brunetti, Stefano Dughetti, David H. Van Thiel, Carlo Scotti-Foglieni

Research output: Contribution to journalArticlepeer-review


Three different approaches to hepatic abscesses due to Entamoeba histolytica were compared in 51 patients. The three modes of therapy utilized were: medical therapy with nitroimidazoles (N=11 patients), open surgical drainage (N=9 patients), and percutaneous drainage using ultrasound guidance followed by intralesional nitroimidazole administration (N=31 patients). The results with each form of therapy were assessed clinically and by abdominal ultrasound. Patients receiving combined US-guided drainage and intralesional chemotherapy experienced a faster and overall better clinical response, which was confirmed also by sonographic follow-up of the hepatic lesions. This better response was associated with faster resolution, fewer relapses, and less residual hepatic scarring than either with medical therapy alone or open surgical drainage combined with medical therapy.

Original languageEnglish
Pages (from-to)240-247
Number of pages8
JournalDigestive Diseases and Sciences
Issue number2
Publication statusPublished - Feb 1992


  • hepatic amebic abscess
  • nitroimidazoles
  • percutaneous drainage
  • surgical drainage
  • ultrasonography

ASJC Scopus subject areas

  • Gastroenterology


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