Osmolar changes and neural activity in frog vestibular organs

G. Zucca, A. Maracci, V. Milesi, M. Trimarchi, E. Mira, M. Manfrin, S. Quaglieri, P. Valli

Research output: Contribution to journalArticlepeer-review


The effects of hypotonic and hypertonic solutions (the normal value was 240 mOsm) on posterior canal resting and evoked discharge were studied in isolated labyrinth preparations. Hypotonic solutions (60 180 mOsm) were obtained by reducing the perilymphatic NaCl content. Hypertonic solutions (300 420 mOsm) were obtained by adding to normal perilymphatic solutions suitable amounts of NaCl. glucose, sucrose, glycerol, mannitol and urea. The results demonstrated that any kind of receptor activity was inhibited by hypotonic solutions. On the contrary, hypertonic solutions produced different effects on resting and evoked activity. The resting discharge was, with the exception of urea, constantly increased whereas the evoked responses were constantly decreased by all the hypertonic solutions tested. The possible effects of media with changed osinolarily in Meniere's patients is also discussed.

Original languageEnglish
Pages (from-to)34-39
Number of pages6
JournalActa Oto-Laryngologica
Issue number1
Publication statusPublished - 1995


  • Endolymphatic hydrops
  • Meniere's disease
  • Osmolar effects
  • Vestibular organs

ASJC Scopus subject areas

  • Otorhinolaryngology


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