TY - JOUR
T1 - Osmolar changes and neural activity in frog vestibular organs
AU - Zucca, G.
AU - Maracci, A.
AU - Milesi, V.
AU - Trimarchi, M.
AU - Mira, E.
AU - Manfrin, M.
AU - Quaglieri, S.
AU - Valli, P.
PY - 1995
Y1 - 1995
N2 - The effects of hypotonic and hypertonic solutions (the normal value was 240 mOsm) on posterior canal resting and evoked discharge were studied in isolated labyrinth preparations. Hypotonic solutions (60 180 mOsm) were obtained by reducing the perilymphatic NaCl content. Hypertonic solutions (300 420 mOsm) were obtained by adding to normal perilymphatic solutions suitable amounts of NaCl. glucose, sucrose, glycerol, mannitol and urea. The results demonstrated that any kind of receptor activity was inhibited by hypotonic solutions. On the contrary, hypertonic solutions produced different effects on resting and evoked activity. The resting discharge was, with the exception of urea, constantly increased whereas the evoked responses were constantly decreased by all the hypertonic solutions tested. The possible effects of media with changed osinolarily in Meniere's patients is also discussed.
AB - The effects of hypotonic and hypertonic solutions (the normal value was 240 mOsm) on posterior canal resting and evoked discharge were studied in isolated labyrinth preparations. Hypotonic solutions (60 180 mOsm) were obtained by reducing the perilymphatic NaCl content. Hypertonic solutions (300 420 mOsm) were obtained by adding to normal perilymphatic solutions suitable amounts of NaCl. glucose, sucrose, glycerol, mannitol and urea. The results demonstrated that any kind of receptor activity was inhibited by hypotonic solutions. On the contrary, hypertonic solutions produced different effects on resting and evoked activity. The resting discharge was, with the exception of urea, constantly increased whereas the evoked responses were constantly decreased by all the hypertonic solutions tested. The possible effects of media with changed osinolarily in Meniere's patients is also discussed.
KW - Endolymphatic hydrops
KW - Meniere's disease
KW - Osmolar effects
KW - Vestibular organs
UR - http://www.scopus.com/inward/record.url?scp=0028868123&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028868123&partnerID=8YFLogxK
U2 - 10.3109/00016489509133343
DO - 10.3109/00016489509133343
M3 - Article
C2 - 7762382
AN - SCOPUS:0028868123
SN - 0001-6489
VL - 115
SP - 34
EP - 39
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 1
ER -