Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and drosophila

Antonio Simeone, Maria Rosaria D'Apice, Vincenzo Nigro, Jordi Casanova, Franco Graziani, Dario Acampora, Virginia Avantaggiato

Research output: Contribution to journalArticlepeer-review


A novel homeobox-containing gene has been identified. Its name, Orthopedia (Otp), exemplifies the homology shared by both the rthodenticle and Antennapedia homeodomains. Otp is highly conserved in evolution. In mouse, Otp is expressed only in restricted domains of the developing forebrain, hindbrain, and spinal cord. In Drosophila, otp first appears at gastrulation in the ectodermal proctodeum and later in the hindgut, anal plate, and along the CNS. Here, we compare the Otp-, Distal-less homeobox 1-(Dix1-), Orthodenticle homolog 1- (Otxl-), Otx2-, and Empty spiracles homolog 2-expressing domains. Our results indicate that Otp is expressed along the CNS both in mouse and Drosophila; Otp could specify regional identities in the development of the forebrain and spinal cord; transcription of Otp and Dlx1 takes place in alternating hypothalamic regions reminiscent of a segment-like pattern; and the structural and functional conservation could correspond to a conserved function maintained in evolution.

Original languageEnglish
Pages (from-to)83-101
Number of pages19
Issue number1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Neuroscience(all)


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