TY - JOUR
T1 - Organ preservation and late functional outcome in oropharyngeal carcinoma
T2 - Rationale of eortc 1420, the “best of” trial
AU - Stelmes, Jean Jacques
AU - Gregoire, Vincent
AU - Poorten, Vincent Vander
AU - Golusiñski, Wojciech
AU - Szewczyk, Mateusz
AU - Jones, Terry
AU - Ansarin, Mohssen
AU - Broglie, Martina A.
AU - Giger, Roland
AU - Klussmann, Jens Peter
AU - Evans, Mererid
AU - Bourhis, Jean
AU - Leemans, C. René
AU - Spriano, Giuseppe
AU - Dietz, Andreas
AU - Hunter, Keith
AU - Zimmermann, Frank
AU - Tinhofer, Ingeborg
AU - Patterson, Joanne M.
AU - Quaglini, Silvana
AU - Govaerts, Anne Sophie
AU - Fortpied, Catherine
AU - Simon, Christian
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early-and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 “Best of” trial, and highlight the potential of this study to help prioritizing either surgery-or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.
AB - Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early-and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 “Best of” trial, and highlight the potential of this study to help prioritizing either surgery-or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.
KW - EORTC 1420
KW - Functional outcome
KW - Head and neck cancer
KW - Organ preservation
KW - Oropharyngeal cancer
UR - http://www.scopus.com/inward/record.url?scp=85074526384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074526384&partnerID=8YFLogxK
U2 - 10.3389/fonc.2019.00999
DO - 10.3389/fonc.2019.00999
M3 - Article
AN - SCOPUS:85074526384
SN - 2234-943X
VL - 9
JO - Frontiers in Oncology
JF - Frontiers in Oncology
IS - OCT
M1 - 999
ER -