Oral metronomic vinorelbine in advanced non-small cell lung cancer patients unfit for chemotherapy

Giuseppe L. Banna, Andrea Camerini, Giuseppe Bronte, Giuseppe Anile, Alfredo Addeo, Francesco Rundo, Guido Zanghi, Rohit Lal, Massimo Libra

Research output: Contribution to journalArticlepeer-review


Aim: To explore the feasibility and activity of oral metronomic vinorelbine patients with advanced NSCLC not eligible to standard chemotherapy because of old age (≥70 years), and/or poor Eastern Cooperative Oncology Group performance status (≥2), and/or extensive brain or bone disease, and/or active comorbidities (≥2) requiring for pharmacological treatment. Patients and Methods: In a prospective phase II not randomized study, patients with stage IV NSCLC unfit to chemotherapy were treated with oral metronomic vinorelbine at 30 mg fixed dose three times a week until disease progression. Results: Fifty patients were treated, 19 (38%) in the first-line setting. Five patients (11%) experienced a grade 3 toxicity; no grade 4 toxicity occurred. Overall disease control rate was 32%, 44% and 26% in first and subsequent lines, respectively (p=0.39). Median OS and PFS were 7.3 months (95% confidence interval [CI]=4.7-10.0) and 2.7 months (95%CI=2.0-3.4), respectively. Conclusion: These data support the activity and safety of metronomic vinorelbine in a relevant proportion of patients usually excluded from any specific treatment.

Original languageEnglish
Pages (from-to)3689-3697
Number of pages9
JournalAnticancer Research
Issue number6
Publication statusPublished - Jun 1 2018


  • Comorbidity
  • Elderly
  • Non-small cell lung cancer
  • Oral metronomic vinorelbine
  • Poor performance status
  • Unfit

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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