TY - JOUR
T1 - Optimization of flow reserve measurement using SPECT technology to evaluate the determinants of coronary microvascular dysfunction in diabetes
AU - Marini, Cecilia
AU - Bezante, Gianpaolo
AU - Gandolfo, Patrizia
AU - Modonesi, Elisa
AU - Morbelli, Silvia D.
AU - Depascale, Angelo
AU - Rollando, Daniela
AU - Maggi, Davide
AU - Albertelli, Manuela
AU - Armonino, Riccardo
AU - Balbi, Manrico
AU - Brunelli, Claudio
AU - Cordera, Renzo
AU - Sambuceti, Gianmario
PY - 2010/2
Y1 - 2010/2
N2 - Purpose: The aim of this study was to validate a new method to measure regional myocardial perfusion reserve (MPR) with technetium-labelled tracers in patients with type 2 diabetes mellitus (DM2). Methods: A total of 40 consecutive DM2 patients without history of coronary artery disease (CAD) and 7 control subjects were recruited. Dipyridamole myocardial blood flow index (MBF) was assessed by measuring first transit counts in the pulmonary artery and myocardial count rate from gated SPECT images using 99mTc-labelled tracers. The corresponding MBF index was estimated 2 h later according to the same procedure. Regional myocardial perfusion reserve (MPR) was defined as the ratio between dipyridamole and baseline MBF using a 17-segment left ventricular (LV) model. Coronary flow reserve (CFR) was estimated by transthoracic contrast echo Doppler monitoring of flow velocity in the left anterior descending coronary artery (LAD) during the same session. Results: Estimated MPR was higher in control subjects than in patients (3.36±0.66 vs 1.91±0.61, respectively, p
AB - Purpose: The aim of this study was to validate a new method to measure regional myocardial perfusion reserve (MPR) with technetium-labelled tracers in patients with type 2 diabetes mellitus (DM2). Methods: A total of 40 consecutive DM2 patients without history of coronary artery disease (CAD) and 7 control subjects were recruited. Dipyridamole myocardial blood flow index (MBF) was assessed by measuring first transit counts in the pulmonary artery and myocardial count rate from gated SPECT images using 99mTc-labelled tracers. The corresponding MBF index was estimated 2 h later according to the same procedure. Regional myocardial perfusion reserve (MPR) was defined as the ratio between dipyridamole and baseline MBF using a 17-segment left ventricular (LV) model. Coronary flow reserve (CFR) was estimated by transthoracic contrast echo Doppler monitoring of flow velocity in the left anterior descending coronary artery (LAD) during the same session. Results: Estimated MPR was higher in control subjects than in patients (3.36±0.66 vs 1.91±0.61, respectively, p
KW - Gated SPECT
KW - Myocardial perfusion reserve
KW - Transthoracic contrast echo Doppler
KW - Type 2 diabetes mellitus
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U2 - 10.1007/s00259-009-1316-5
DO - 10.1007/s00259-009-1316-5
M3 - Article
C2 - 19957177
AN - SCOPUS:77949271483
SN - 0340-6199
VL - 37
SP - 357
EP - 367
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 2
ER -