Oocyte Retrieval during Laparoscopic Vaginoplasty to Reduce Invasiveness in the Treatment of Mayer-Rokitansky-Küster-Hauser Syndrome

Massimo Candiani, Valeria S. Vanni, Enrico Papaleo, Diana Delprato, Iacopo Tandoi, Valeria Gervasio, Marta Parma, Laura Corti, Serena Girardelli, Luigi Fedele

Research output: Contribution to journalArticlepeer-review


Study Objective: To evaluate the treatment of patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome with a combination of oocyte retrieval and surgical vaginoplasty in a single laparoscopic procedure. Design: A case series. Setting: The study was conducted at 2 tertiary referral facilities for MRKH syndrome in Milan, Italy, between July 2017 and September 2018. Patients: Eleven patients presented with MRKH and required surgical vaginoplasty while expressing a desire for future fertility. Interventions: Two experienced surgeons and an expert in assisted reproductive technology performed concomitant vaginoplasty according to the modified technique of Davydov and laparoscopic oocyte retrieval for gamete cryopreservation. Measurements and Main Results: Before the procedure, patients underwent extensive counseling and gave written consent. At the start of surgery, 10.4 ± 4.4 (mean ± standard deviation [SD]) oocytes were retrieved laparoscopically, and 8.8 ± 3.1 (SD) mean mature oocytes were cryopreserved. After oocyte retrieval, the steps of the modified Davydov technique were followed. The total operative time was 116 ± 16 minutes (mean ± SD), and no intraoperative/postoperative complications were observed. Conclusion: This is the first report of combined oocyte retrieval and vaginoplasty for patients with MRKH syndrome. The approach was found to be feasible in patients with a desire for future fertility. It is our belief that physicians treating patients with MRKH should refer patients to centers with expertise in both vaginoplasty and assisted reproductive technology.

Original languageEnglish
Pages (from-to)74-79
JournalJournal of Minimally Invasive Gynecology
Issue number1
Publication statusPublished - 2020


  • Assisted reproductive technology
  • Davydov technique
  • Gamete cryopreservation
  • Mayer-Rokitansky-Küster-Hauser syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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