Abstract
Molecular and genetic analyses of tumor cell show that cellular oncogenes and suppressor genes are involved in neoplastic transformation. In pediatric tumors oncogenes as N-myc play an important role in the tumor progression. In retinoblastoma, neuroblastoma, Wilms' tumor, and rhabdomyosarcoma loss of heterozygosity for specific chromosome loci has been suggested to be a critical step in cancer development. Oncogene abnormalities can also be useful as a molecular tumor factor to foresee the prognosis of the disease. The present article is a review on the role of the oncogenes and suppressor genes in pediatric solid tumors.
| Translated title of the contribution | Oncogenes and suppressor genes in the genesis and progression of solid tumors in children |
|---|---|
| Original language | Italian |
| Pages (from-to) | 203-209 |
| Number of pages | 7 |
| Journal | Pediatria Medica e Chirurgica |
| Volume | 16 |
| Issue number | 3 |
| Publication status | Published - May 1994 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health