Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number

Gianluca Marucci; Alessandra Maresca; Leonardo Caporali; Anna Farnedi; Christine Margaret Betts; Luca Morandi; Dario De Biase; Serenella Cerasoli; Maria Pia Foschini; Elena Bonora; Michele Vidone; Giovanni Romeo; Elena Perli; Carla Giordano; Giulia D'Amati; Giuseppe Gasparre; Agostino Baruzzi; Valerio Carelli; Vincenzo Eusebi

doi:10.1016/j.humpath.2013.02.014

Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number

Gianluca Marucci, Alessandra Maresca, Leonardo Caporali, Anna Farnedi, Christine Margaret Betts, Luca Morandi, Dario De Biase, Serenella Cerasoli, Maria Pia Foschini, Elena Bonora, Michele Vidone, Giovanni Romeo, Elena Perli, Carla Giordano, Giulia D'Amati, Giuseppe Gasparre, Agostino Baruzzi, Valerio Carelli, Vincenzo Eusebi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Ten cases of glioblastomas showing oncocytic changes are described. The tumors showed mononuclear to multinuclear cells and abundant, granular, eosinophilic cytoplasm. The cytoplasm of these same cells was filled by strongly immunoreactive mitochondria. At ultrastructure, numerous mitochondria, some of which were large, were evidenced in the cytoplasm of neoplastic cells. Finally, 9 of 10 of these cases had a significantly high mitochondrial DNA content compared with control tissue (P

Original language	English
Pages (from-to)	1867-1876
Number of pages	10
Journal	Human Pathology
Volume	44
Issue number	9
DOIs	https://doi.org/10.1016/j.humpath.2013.02.014
Publication status	Published - Sept 2013

Keywords

Glioblastoma
mtDNA
Oncocytic features

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.humpath.2013.02.014

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Marucci, G., Maresca, A., Caporali, L., Farnedi, A., Betts, C. M., Morandi, L., De Biase, D., Cerasoli, S., Foschini, M. P., Bonora, E., Vidone, M., Romeo, G., Perli, E., Giordano, C., D'Amati, G., Gasparre, G., Baruzzi, A., Carelli, V., & Eusebi, V. (2013). Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number. Human Pathology, 44(9), 1867-1876. https://doi.org/10.1016/j.humpath.2013.02.014

Marucci, G, Maresca, A, Caporali, L, Farnedi, A, Betts, CM, Morandi, L, De Biase, D, Cerasoli, S, Foschini, MP, Bonora, E, Vidone, M, Romeo, G, Perli, E, Giordano, C, D'Amati, G, Gasparre, G, Baruzzi, A, Carelli, V & Eusebi, V 2013, 'Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number', Human Pathology, vol. 44, no. 9, pp. 1867-1876. https://doi.org/10.1016/j.humpath.2013.02.014

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title = "Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number",

abstract = "Ten cases of glioblastomas showing oncocytic changes are described. The tumors showed mononuclear to multinuclear cells and abundant, granular, eosinophilic cytoplasm. The cytoplasm of these same cells was filled by strongly immunoreactive mitochondria. At ultrastructure, numerous mitochondria, some of which were large, were evidenced in the cytoplasm of neoplastic cells. Finally, 9 of 10 of these cases had a significantly high mitochondrial DNA content compared with control tissue (P ",

keywords = "Glioblastoma, mtDNA, Oncocytic features",

author = "Gianluca Marucci and Alessandra Maresca and Leonardo Caporali and Anna Farnedi and Betts, {Christine Margaret} and Luca Morandi and {De Biase}, Dario and Serenella Cerasoli and Foschini, {Maria Pia} and Elena Bonora and Michele Vidone and Giovanni Romeo and Elena Perli and Carla Giordano and Giulia D'Amati and Giuseppe Gasparre and Agostino Baruzzi and Valerio Carelli and Vincenzo Eusebi",

year = "2013",

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doi = "10.1016/j.humpath.2013.02.014",

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AU - Marucci, Gianluca

AU - Maresca, Alessandra

AU - Caporali, Leonardo

AU - Farnedi, Anna

AU - Betts, Christine Margaret

AU - Morandi, Luca

AU - De Biase, Dario

AU - Cerasoli, Serenella

AU - Foschini, Maria Pia

AU - Bonora, Elena

AU - Vidone, Michele

AU - Romeo, Giovanni

AU - Perli, Elena

AU - Giordano, Carla

AU - D'Amati, Giulia

AU - Gasparre, Giuseppe

AU - Baruzzi, Agostino

AU - Carelli, Valerio

AU - Eusebi, Vincenzo

PY - 2013/9

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AB - Ten cases of glioblastomas showing oncocytic changes are described. The tumors showed mononuclear to multinuclear cells and abundant, granular, eosinophilic cytoplasm. The cytoplasm of these same cells was filled by strongly immunoreactive mitochondria. At ultrastructure, numerous mitochondria, some of which were large, were evidenced in the cytoplasm of neoplastic cells. Finally, 9 of 10 of these cases had a significantly high mitochondrial DNA content compared with control tissue (P

KW - Glioblastoma

KW - mtDNA

KW - Oncocytic features

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Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number

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Keywords

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