OCT-guided photodynamic therapy for angiographic occult CNV in pathologic myopia

Paolo Milani, L. Pierro, A. Scialdone

Research output: Contribution to journalArticlepeer-review


Purpose. Pathologic myopia (PM) is frequently complicated by choroidal neovascularization (CNV). Diagnosis is mainly clinical and angiographic but in recent years optical coherence tomography (OCT) has been noted to add important information. The authors report on the successfully OCT-guided photodynamic therapy (PDT) of an angiographic occult CNV complicating PM. Methods. Observational case report. Fluorescein angiography with a confocal SLO (HRA, Heidelberg Engineering, Germany) and OCT Stratus (Carl Zeiss Meditec, Inc.) imaging were used for diagnosis and monitoring of the CNV. Standard PDT was performed. Results. A highly myopic 17-year-old girl complained of a drop in visual acuity (VA) in left eye (LE), dating back a few weeks. Her best-corrected (BC) VA was 20/40 in the LE, with some metamorphopsia. No hemorrhage or evident signs of CNV were visible either at fundus or at dynamic fluorescein angiography. OCT scans indicated a slight elevation of the RPE-choriocapillary complex with rarefaction of neuroretinal tissue that has been interpreted as CNV. PDT was then performed. LE BCVA had improved to 20/25, metamorphopsias disappeared, and at OCT examination no retinal morphologic modification was evident. Nine months later, BCVA and ophthalmoscopy are still stable. Conclusions. In this case, OCT was the fundamental tool for the correct diagnosis and post-therapy monitoring of CNV-complicated PM. The CNV, not clearly detectable using angiographic imaging, was treated with PDT, and results in terms of VA and anatomic resolution were good.

Original languageEnglish
Pages (from-to)837-840
Number of pages4
JournalEuropean Journal of Ophthalmology
Issue number5
Publication statusPublished - Sept 2008


  • CNV in myopia
  • OCT and CNV
  • OCT and myopia
  • Pathologic myopia
  • PDT in myopia

ASJC Scopus subject areas

  • Ophthalmology


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