Observer agreement on the grading of gastric atrophy

G. J A Offerhaus, A. B. Price, J. Haot, F. J W ten Kate, P. Sipponen, R. Fiocca, M. Stolte, M. F. Dixon

Research output: Contribution to journalArticlepeer-review


Aims: Assessment of lesser or doubtful degrees of gastric atrophy can be difficult, especially in the antrum, since well established criteria are lacking. At the Houston Working Party on Gastritis in 1994 a visual analogue scale was designed for the grading of histopathological parameters. This was done to promote uniformity in grading by acting as a reference. The purpose of the present study was to measure interobserver variation between pathologists familiar with the Houston visual analogue scale in a specifically selected set of biopsies from patients with lesser or doubtful degrees of atrophy. Methods and results: Thirty cases with biopsies of the antrum and corpus from a long-term follow-up study on Helicobacter pylori gastritis comprised the current study material. The cases were selected from that study because there had been uncertainty or disagreement on the presence of gastric atrophy. The study set of haematoxylin and eosin (H and E) slides was circulated amongst gastrointestinal pathologists familiar with the visual analogue scale who were unaware of the source of the study set nor had any other clinical information. Interobserver variability was analysed using kappa statistics. The overall agreement for the grade of atrophy in antral biopsies was 0.461; the kappa value was 0.18 (95% confidence limits 0.12- 0.24), which is considered poor agreement. The kappa value was nevertheless statistically significant (P

Original languageEnglish
Pages (from-to)320-325
Number of pages6
Issue number4
Publication statusPublished - 1999


  • Criteria
  • Gastric atrophy
  • Guidelines
  • Interobserver variability
  • Kappa statistic

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology


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