Obesity worsens central inflammation and disability in multiple sclerosis

Mario Stampanoni Bassi; Ennio Iezzi; Fabio Buttari; Luana Gilio; Ilaria Simonelli; Fortunata Carbone; Teresa Micillo; Veronica De Rosa; Francesco Sica; Roberto Furlan; Annamaria Finardi; Roberta Fantozzi; Marianna Storto; Paolo Bellantonio; Pamela Pirollo; Sonia Di Lemme; Alessandra Musella; Georgia Mandolesi; Diego Centonze; Giuseppe Matarese

doi:10.1177/1352458519853473

Obesity worsens central inflammation and disability in multiple sclerosis

Mario Stampanoni Bassi, Ennio Iezzi, Fabio Buttari, Luana Gilio, Ilaria Simonelli, Fortunata Carbone, Teresa Micillo, Veronica De Rosa, Francesco Sica, Roberto Furlan, Annamaria Finardi, Roberta Fantozzi, Marianna Storto, Paolo Bellantonio, Pamela Pirollo, Sonia Di Lemme, Alessandra Musella, Georgia Mandolesi, Diego Centonze, Giuseppe Matarese

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Abstract

BACKGROUND: Previous studies evidenced a link between metabolic dysregulation, inflammation, and neurodegeneration in multiple sclerosis (MS).

OBJECTIVES: To explore whether increased adipocyte mass expressed as body mass index (BMI) and increased serum lipids influence cerebrospinal fluid (CSF) inflammation and disease severity.

METHODS: In this cross-sectional study, 140 consecutive relapsing-remitting (RR)-MS patients underwent clinical assessment, BMI evaluation, magnetic resonance imaging scan, and blood and CSF collection before any specific drug treatment. The CSF levels of the following cytokines, adipocytokines, and inflammatory factors were measured: interleukin (IL)-6, IL-13, granulocyte macrophage colony-stimulating factor, leptin, ghrelin, osteoprotegerin, osteopontin, plasminogen activator inhibitor-1, resistin, and Annexin A1. Serum levels of triglycerides, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were assessed.

RESULTS: A positive correlation emerged between BMI and Expanded Disability Status Scale score. Obese RR-MS patients showed higher clinical disability, increased CSF levels of the proinflammatory molecules IL-6 and leptin, and reduced concentrations of the anti-inflammatory cytokine IL-13. Moreover, both the serum levels of triglycerides and TC/HDL-C ratio showed a positive correlation with IL-6 CSF concentrations.

CONCLUSION: Obesity and altered lipid profile are associated with exacerbated central inflammation and higher clinical disability in RR-MS at the time of diagnosis. Increased adipocytokines and lipids can mediate the negative impact of high adiposity on RR-MS course.

Original language	English
Pages (from-to)	1352458519853473
Journal	Multiple Sclerosis
DOIs	https://doi.org/10.1177/1352458519853473
Publication status	E-pub ahead of print - Jun 4 2019

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Stampanoni Bassi, M., Iezzi, E., Buttari, F., Gilio, L., Simonelli, I., Carbone, F., Micillo, T., De Rosa, V., Sica, F., Furlan, R., Finardi, A., Fantozzi, R., Storto, M., Bellantonio, P., Pirollo, P., Di Lemme, S., Musella, A., Mandolesi, G., Centonze, D., & Matarese, G. (2019). Obesity worsens central inflammation and disability in multiple sclerosis. Multiple Sclerosis, 1352458519853473. https://doi.org/10.1177/1352458519853473

Stampanoni Bassi, M , Iezzi, E , Buttari, F , Gilio, L, Simonelli, I, Carbone, F, Micillo, T, De Rosa, V, Sica, F, Furlan, R, Finardi, A, Fantozzi, R , Storto, M , Bellantonio, P, Pirollo, P, Di Lemme, S, Musella, A, Mandolesi, G, Centonze, D & Matarese, G 2019, 'Obesity worsens central inflammation and disability in multiple sclerosis', Multiple Sclerosis, pp. 1352458519853473. https://doi.org/10.1177/1352458519853473

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title = "Obesity worsens central inflammation and disability in multiple sclerosis",

abstract = "BACKGROUND: Previous studies evidenced a link between metabolic dysregulation, inflammation, and neurodegeneration in multiple sclerosis (MS).OBJECTIVES: To explore whether increased adipocyte mass expressed as body mass index (BMI) and increased serum lipids influence cerebrospinal fluid (CSF) inflammation and disease severity.METHODS: In this cross-sectional study, 140 consecutive relapsing-remitting (RR)-MS patients underwent clinical assessment, BMI evaluation, magnetic resonance imaging scan, and blood and CSF collection before any specific drug treatment. The CSF levels of the following cytokines, adipocytokines, and inflammatory factors were measured: interleukin (IL)-6, IL-13, granulocyte macrophage colony-stimulating factor, leptin, ghrelin, osteoprotegerin, osteopontin, plasminogen activator inhibitor-1, resistin, and Annexin A1. Serum levels of triglycerides, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were assessed.RESULTS: A positive correlation emerged between BMI and Expanded Disability Status Scale score. Obese RR-MS patients showed higher clinical disability, increased CSF levels of the proinflammatory molecules IL-6 and leptin, and reduced concentrations of the anti-inflammatory cytokine IL-13. Moreover, both the serum levels of triglycerides and TC/HDL-C ratio showed a positive correlation with IL-6 CSF concentrations.CONCLUSION: Obesity and altered lipid profile are associated with exacerbated central inflammation and higher clinical disability in RR-MS at the time of diagnosis. Increased adipocytokines and lipids can mediate the negative impact of high adiposity on RR-MS course.",

author = "{Stampanoni Bassi}, Mario and Ennio Iezzi and Fabio Buttari and Luana Gilio and Ilaria Simonelli and Fortunata Carbone and Teresa Micillo and {De Rosa}, Veronica and Francesco Sica and Roberto Furlan and Annamaria Finardi and Roberta Fantozzi and Marianna Storto and Paolo Bellantonio and Pamela Pirollo and {Di Lemme}, Sonia and Alessandra Musella and Georgia Mandolesi and Diego Centonze and Giuseppe Matarese",

year = "2019",

month = jun,

day = "4",

doi = "10.1177/1352458519853473",

language = "English",

pages = "1352458519853473",

journal = "Multiple Sclerosis",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

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TY - JOUR

T1 - Obesity worsens central inflammation and disability in multiple sclerosis

AU - Stampanoni Bassi, Mario

AU - Iezzi, Ennio

AU - Buttari, Fabio

AU - Gilio, Luana

AU - Simonelli, Ilaria

AU - Carbone, Fortunata

AU - Micillo, Teresa

AU - De Rosa, Veronica

AU - Sica, Francesco

AU - Furlan, Roberto

AU - Finardi, Annamaria

AU - Fantozzi, Roberta

AU - Storto, Marianna

AU - Bellantonio, Paolo

AU - Pirollo, Pamela

AU - Di Lemme, Sonia

AU - Musella, Alessandra

AU - Mandolesi, Georgia

AU - Centonze, Diego

AU - Matarese, Giuseppe

PY - 2019/6/4

Y1 - 2019/6/4

N2 - BACKGROUND: Previous studies evidenced a link between metabolic dysregulation, inflammation, and neurodegeneration in multiple sclerosis (MS).OBJECTIVES: To explore whether increased adipocyte mass expressed as body mass index (BMI) and increased serum lipids influence cerebrospinal fluid (CSF) inflammation and disease severity.METHODS: In this cross-sectional study, 140 consecutive relapsing-remitting (RR)-MS patients underwent clinical assessment, BMI evaluation, magnetic resonance imaging scan, and blood and CSF collection before any specific drug treatment. The CSF levels of the following cytokines, adipocytokines, and inflammatory factors were measured: interleukin (IL)-6, IL-13, granulocyte macrophage colony-stimulating factor, leptin, ghrelin, osteoprotegerin, osteopontin, plasminogen activator inhibitor-1, resistin, and Annexin A1. Serum levels of triglycerides, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were assessed.RESULTS: A positive correlation emerged between BMI and Expanded Disability Status Scale score. Obese RR-MS patients showed higher clinical disability, increased CSF levels of the proinflammatory molecules IL-6 and leptin, and reduced concentrations of the anti-inflammatory cytokine IL-13. Moreover, both the serum levels of triglycerides and TC/HDL-C ratio showed a positive correlation with IL-6 CSF concentrations.CONCLUSION: Obesity and altered lipid profile are associated with exacerbated central inflammation and higher clinical disability in RR-MS at the time of diagnosis. Increased adipocytokines and lipids can mediate the negative impact of high adiposity on RR-MS course.

AB - BACKGROUND: Previous studies evidenced a link between metabolic dysregulation, inflammation, and neurodegeneration in multiple sclerosis (MS).OBJECTIVES: To explore whether increased adipocyte mass expressed as body mass index (BMI) and increased serum lipids influence cerebrospinal fluid (CSF) inflammation and disease severity.METHODS: In this cross-sectional study, 140 consecutive relapsing-remitting (RR)-MS patients underwent clinical assessment, BMI evaluation, magnetic resonance imaging scan, and blood and CSF collection before any specific drug treatment. The CSF levels of the following cytokines, adipocytokines, and inflammatory factors were measured: interleukin (IL)-6, IL-13, granulocyte macrophage colony-stimulating factor, leptin, ghrelin, osteoprotegerin, osteopontin, plasminogen activator inhibitor-1, resistin, and Annexin A1. Serum levels of triglycerides, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were assessed.RESULTS: A positive correlation emerged between BMI and Expanded Disability Status Scale score. Obese RR-MS patients showed higher clinical disability, increased CSF levels of the proinflammatory molecules IL-6 and leptin, and reduced concentrations of the anti-inflammatory cytokine IL-13. Moreover, both the serum levels of triglycerides and TC/HDL-C ratio showed a positive correlation with IL-6 CSF concentrations.CONCLUSION: Obesity and altered lipid profile are associated with exacerbated central inflammation and higher clinical disability in RR-MS at the time of diagnosis. Increased adipocytokines and lipids can mediate the negative impact of high adiposity on RR-MS course.

U2 - 10.1177/1352458519853473

DO - 10.1177/1352458519853473

M3 - Article

C2 - 31161863

SN - 1352-4585

SP - 1352458519853473

JO - Multiple Sclerosis

JF - Multiple Sclerosis

ER -

Obesity worsens central inflammation and disability in multiple sclerosis

Abstract

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