TY - JOUR
T1 - Obesity, type 2 diabetes mellitus and cardiovascular disease risk
T2 - An uptodate in the management of polycystic ovary syndrome
AU - Orio, Francesco
AU - Muscogiuri, G.
AU - Nese, Cinar
AU - Palomba, Stefano
AU - Savastano, S.
AU - Tafuri, D.
AU - Colarieti, Giorgio
AU - La Sala, Giovanbattista
AU - Colao, A.
AU - Yildiz, B. O.
PY - 2016/6/22
Y1 - 2016/6/22
N2 - Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women and is characterized by two of the following three features: oligoovulation or anovulation, clinical and/or biochemical signs of hyperandrogenism, or polycystic ovaries. Summary: It has been demonstrated that PCOS includes a complex number of systemic symptoms in addition to symptoms related to the reproductive apparatus. It has been associated with obesity, metabolic syndrome, type 2 diabetes and an increased risk of cardiovascular disease. Several clinical and basic studies have investigated the link between PCOS and the cardiovascular disease risk, which seems to be due to blunted lipid/glucose metabolism, hypertension, and systemic inflammatory and coagulation disorders. Therefore, the current manuscript aims to review the main findings on PCOS and obesity/. obesity-related disease (glucose derangements and cardiovascular disease risk factors). Key message: Although there are no long-term data on the morbidity and mortality for cardiovascular disease in PCOS, it is advisable to perform a careful metabolic and cardiovascular assessment in women with PCOS in order to tailor the most suitable strategy to prevent cardiovascular disease.
AB - Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women and is characterized by two of the following three features: oligoovulation or anovulation, clinical and/or biochemical signs of hyperandrogenism, or polycystic ovaries. Summary: It has been demonstrated that PCOS includes a complex number of systemic symptoms in addition to symptoms related to the reproductive apparatus. It has been associated with obesity, metabolic syndrome, type 2 diabetes and an increased risk of cardiovascular disease. Several clinical and basic studies have investigated the link between PCOS and the cardiovascular disease risk, which seems to be due to blunted lipid/glucose metabolism, hypertension, and systemic inflammatory and coagulation disorders. Therefore, the current manuscript aims to review the main findings on PCOS and obesity/. obesity-related disease (glucose derangements and cardiovascular disease risk factors). Key message: Although there are no long-term data on the morbidity and mortality for cardiovascular disease in PCOS, it is advisable to perform a careful metabolic and cardiovascular assessment in women with PCOS in order to tailor the most suitable strategy to prevent cardiovascular disease.
KW - Cardiovascular disease
KW - Environment
KW - Lifestyle
KW - Obesity
KW - PCOS
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84994115576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994115576&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2016.08.026
DO - 10.1016/j.ejogrb.2016.08.026
M3 - Article
SN - 0028-2243
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
ER -