Nutritional assessment in idiopathic pulmonary fibrosis: a prospective multicentre study

Paola Faverio, Alessia Fumagalli, Sara Conti, Fabiana Madotto, Francesco Bini, Sergio Harari, Michele Mondoni, Tiberio Oggionni, Emanuela Barisione, Paolo Ceruti, Maria Chiara Papetti, Bruno Dino Bodini, Antonella Caminati, Angela Valentino, Stefano Centanni, Donatella Noè, Matteo Della Zoppa, Silvia Crotti, Marco Grosso, Samir Giuseppe SukkarDenise Modina, Marco Andreoli, Roberta Nicali, Giulia Suigo, Federica De Giacomi, Sara Busnelli, Elena Cattaneo, Lorenzo Giovanni Mantovani, Giancarlo Cesana, Alberto Pesci, Fabrizio Luppi

Research output: Contribution to journalArticlepeer-review


Background Nutritional status impacts quality of life and prognosis of patients with respiratory diseases, including idiopathic pulmonary fibrosis (IPF). However, there is a lack of studies performing an extensive nutritional assessment of IPF patients. This study aimed to investigate the nutritional status and to identify nutritional phenotypes in a cohort of IPF patients at diagnosis. Methods Patients underwent a thorough pulmonary and nutritional evaluation including questionnaires on nutritional status, and physical activity, anthropometry, body impedance, dynamometry, 4-m gait speed and blood tests. Results 90 IPF patients (78.9% males, mean age 72.7 years) were enrolled. The majority of patients were classified as Gender-Age-Physiology Index stage 2 (47, 52.2%) with an inactive lifestyle according to International Physical Activity Questionnaire score (39, 43.3%), and had mean forced vital capacity and diffusing capacity for carbon monoxide 86.5% and 54.2%, respectively. In regards to nutritional phenotypes, the majority of patients were normally nourished (67.8%, 95% CI 58.6–77.7%), followed by non-sarcopenic obese (25.3%, 95% CI 16.1–35.2%), sarcopenic (4.6%, 95% CI 0.0–14.5%) and sarcopenic obese (2.3%, 95% CI 0.0–12.2%). Among the normally nourished, 49.2% showed early signs of nutritional and physical performance alterations, including body mass index ⩾30 kg·m−2 in 4.3%, history of weight loss ⩾5% in 11.9%, and reduction of gait speed and hand grip strength in 11.9% and 35.6%, respectively. Low vitamin D values were observed in 56.3% of cases. Conclusions IPF patients at diagnosis are mainly normally nourished and obese, but early signs of nutritional and physical performance impairment can already be identified at this stage.

Original languageEnglish
Article number00443-2021
JournalERJ Open Research
Issue number1
Publication statusPublished - Jan 1 2022

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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