TY - CHAP
T1 - Nuclear PI-PLC β1 and myelodysplastic syndromes
T2 - From bench to clinics
AU - Mongiorgi, Sara
AU - Follo, Matilde Y.
AU - Clissa, Cristina
AU - Giardino, Roberto
AU - Fini, Milena
AU - Manzoli, Lucia
AU - Ramazzotti, Giulia
AU - Fiume, Roberta
AU - Finelli, Carlo
AU - Cocco, Lucio
PY - 2012
Y1 - 2012
N2 - Myelodysplastic syndromes (MDS), clonal hematopoietic stem-cell disorders mainly affecting older adult patients, show ineffective hematopoiesis in one or more of the lineages of the bone marrow. A number of MDS progresses to acute myeloid leukemia (AML) with the involvement of genetic and epigenetic mechanisms affecting PI-PLC β1. The molecular mechanisms underlying the MDS evolution to AML are still unclear, even though it is now clear that the nuclear signaling elicited by PI-PLC β1, Cyclin D3, and Akt plays an important role in the control of the balance between cell cycle progression and apoptosis in both normal and pathologic conditions. Moreover, a correlation between other PI-PLCs, such as PI-PLC β3, kinases and phosphatases has been postulated in MDS pathogenesis. Here, we review the findings hinting at the role of nuclear lipid signaling pathways in MDS, which could become promising therapeutic targets.
AB - Myelodysplastic syndromes (MDS), clonal hematopoietic stem-cell disorders mainly affecting older adult patients, show ineffective hematopoiesis in one or more of the lineages of the bone marrow. A number of MDS progresses to acute myeloid leukemia (AML) with the involvement of genetic and epigenetic mechanisms affecting PI-PLC β1. The molecular mechanisms underlying the MDS evolution to AML are still unclear, even though it is now clear that the nuclear signaling elicited by PI-PLC β1, Cyclin D3, and Akt plays an important role in the control of the balance between cell cycle progression and apoptosis in both normal and pathologic conditions. Moreover, a correlation between other PI-PLCs, such as PI-PLC β3, kinases and phosphatases has been postulated in MDS pathogenesis. Here, we review the findings hinting at the role of nuclear lipid signaling pathways in MDS, which could become promising therapeutic targets.
UR - http://www.scopus.com/inward/record.url?scp=84870031043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870031043&partnerID=8YFLogxK
U2 - 10.1007/978-94-007-5025-8-11
DO - 10.1007/978-94-007-5025-8-11
M3 - Chapter
C2 - 23086421
AN - SCOPUS:84870031043
SN - 9789400750241
VL - 362
T3 - Current Topics in Microbiology and Immunology
SP - 235
EP - 245
BT - Current Topics in Microbiology and Immunology
ER -