Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"

Chiara di Meo; Luigi Panza; Federica Campo; Donatella Capitani; Luisa Mannina; Alessandra Banzato; Maria Rondina; Antonio Rosato; Vittorio Crescenzi

doi:10.1002/mabi.200700304

Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"

Chiara di Meo, Luigi Panza, Federica Campo, Donatella Capitani, Luisa Mannina, Alessandra Banzato, Maria Rondina, Antonio Rosato, Vittorio Crescenzi

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Two new HA derivatives bearing carborane rings were synthesized by click chemistry. The optimal conditions were assessed for the preparation of biocompatible boron carriers, potentially suitable for application in BNCT and capable of targeting the CD44 antigen. The new polymeric samples were characterized by means of NMR-spectroscopy techniques that gave degrees of 17 and 8% for HAAACB and HapACB, respectively. Both HAAACB and HApACB turned out to be nontoxic for colorectal, ovarian and bladder tumor cell lines, to disclose a specific interaction with the CD44 antigen as the native hyaluronan moiety, and to deliver boron-atom concentrations largely sufficient for BNCT therapy when accumulated in cancer cells. A graph is presented.

Original language	English
Pages (from-to)	670-681
Number of pages	12
Journal	Macromolecular Bioscience
Volume	8
Issue number	7
DOIs	https://doi.org/10.1002/mabi.200700304
Publication status	Published - Jul 7 2008

Keywords

Biological applications of polymers
BNCT
Click chemistry
Conjugated polymers
Hyaluronan

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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Cite this

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AU - di Meo, Chiara

AU - Panza, Luigi

AU - Campo, Federica

AU - Capitani, Donatella

AU - Mannina, Luisa

AU - Banzato, Alessandra

AU - Rondina, Maria

AU - Rosato, Antonio

AU - Crescenzi, Vittorio

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Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"

Abstract

Keywords

ASJC Scopus subject areas

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