Novel treatment perspectives from advances in understanding of genetic epilepsy syndromes

Research output: Contribution to journalArticlepeer-review


Introduction: It is increasingly clear that epilepsy is genetically heterogeneous and novel gene discoveries have moved the field beyond the known contribution of ion channels to implicate chromatin remodeling, transcriptional regulation and regulation of cortical development. Although such discoveries pave the way for new therapeutics, relatively little has been written on the potential implications for treatment. We discuss the most recent advances in the field of epilepsy genetics, as facilitated by genomic technologies, and highlight several novel molecular targets and and potential novel therapeutic strategies. Areas covered: Epilepsy molecular mechanisms, genetic epilepsies, novel therapeutic approach. Expert opinion: The genetic confirmation and classification of a clinical diagnosis in an individual provides certainty in treatment decisions, prognosis, and evaluation of seizure recurrence risks and may also prevent unnecessary diagnostic investigations. The growing number of discoveries on this topic may lead to targeted therapeutic approaches in the near future. Only better understanding of mechanisms of epilepsies can result in great improvement of therapy and quality of life of patients.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalExpert Opinion on Orphan Drugs
Publication statusAccepted/In press - Mar 30 2016


  • antiepileptic drugs
  • Epilepsy
  • genetics
  • precision medicine
  • review
  • therapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Health Policy
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)


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